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Introduction
CAS.No | 33286-22-5 |
Product name | Dilthiazem hydrochloride |
MF | C22H27ClN2O4S |
MW | 450.98 |
EINECS | 251-443-3 |
Function
Diltiazem is a nondihydropyridines calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.
Diltiazem relaxes the smooth muscles in the walls of arteries, which opens (dilates) the arteries, allows blood to flow more easily, and lowers blood pressure. Additionally, it lowers blood pressure by acting on the heart itself to reduce the rate, strength, and conduction speed of each beat.
As it mildly suppresses the immune system, it is used in some autoimmune disorders, such as rheumatoid arthritis and lupus erythematosus.
Melting point | 212-214 °C |
alpha | D24 +98.3 ± 1.4° |
density | 1.30 g/cm3 |
refractive index | 118 ° (C=1, H2O) |
Fp | 2ºC |
storage temp. | 2-8°C |
solubility | Freely soluble in water, in methylene chloride, slightly soluble in anhydrous ethanol. |
form | Powder |
color | White to off-white |
PH | pH (10g/l, 25ºC) : 4.3~5.3 |
Water Solubility | soluble |
Merck | 13,3226 |
BRN | 4228706 |