China GMP Factory Direct Supply 99% Purity Griseofulvin Raw Powder CAS: 126-07-8, Find details about China Griseofulvin Powder, Griseofulvin from China GMP Factory Direct Supply 99% Purity Griseofulvin Raw Powder CAS: 126-07-8
Griseofulvin is a non-polyene class antifungal antibiotics; it can strongly inhibit the mitosis of fungal cell and interfere with the fungal DNA synthesis; it can also bind to tubulin to prevent fungal cell division. It has been applied to clinical medicine since 1958 and has currently been widely used for treating the fungal infections of the skin and the stratum corneum with strong inhibitory effects on Trichophyton rubrum and Trichophyton tonsorans, etc. Griseofulvin is not only a widely used antibiotic for clinical treatment of fungal infections of the skin and cuticle, but also applied in agriculture for prevention and treatment of fungal diseases; for example, it has a special efficacy on treating a kind of candidiasis in apple which can cause infection during pollination.
It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants.
Test Items | Specification | Test Results |
Characteristics | A yellowish-white,microfine powder | yellowish-white,microfine powder |
Melting point | 220ºC About 220ºC | 218.4ºC-219.4ºC |
Specific optical rotation | +354o~+364o | +356o |
Identification | Meets the requirements | Meets the requirements |
Check-up Particles size | Meets the requirements | Meets the requirements |
Acidity | 0.25g consumed 0.02mol/l NaOH not more intensely coloured than reference solution Y4 | 0.6ml |
Clarity and colour of solution | The solution is clear and not more intensely coloured than reference solution Y4 | Y5~Y6 Clear Y5~Y6 |
Matter soluble in petroleum spirit | ≤0.2% | 0.1% |
Sulphated ash | ≤0.2% | 0.1% |
Related substances | -Cl:<0.60 -H<0.15 | -Cl:0.48-H:0.04 |
Loss on drying | ≤1.0% | 0.1% |
Abnormal toxicity | Meets the requirements | Meets the requirements |
assay(on the anhydrous substance) | 97.0%~102.0% | 98.3% |
Conclusion | The above certificate of analysis is in compliance with BP/EP,meets the standard requirements. |
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