(1) anti-tumor activity
Rhubarb acid can inhibit melanoma, ascites, liver cancer, breast cancer and P388 leukemia cells.Intraperitoneal injection of rhubarb acid at 50 g/kg for 21 days inhibited mouse melanoma by 76%.The IC50 value of the inhibitory effect on calling was 40 g/kg.One of the inhibitory mechanisms of rhubarb acid on hepatocellular carcinoma in vivo and ascites in mice is its effect on linear stereoscopic and microfilament structures.
(2) antibacterial activity
At a depth of 1.5~25mg/ml, rhubarb acid had inhibitory effects on staphylococcus, streptococcus, diphtheria bacillus, bacillus subtilis, paratyphoid bacillus and dysentery bacillus.One of its effects is to inhibit electron transport in the mitochondrial respiratory chain.Rhubarb acid has a strong inhibitory effect on nucleic acid and protein synthesis of staphylococcus aureus.
(3) immunosuppression
Rhubarb acid can inhibit the production of antibodies, inhibit the ability of carbon clearance, reduce the weight of immune
organs, reduce the number of white blood cells.
(4) diuretic effect
Rhubarb acid can increase the concentration of sodium and potassium ions in urine, promote ureteral peristalsis and increase urine volume.
(5) diarrhea
Rhubarb acid itself has no cathartic effect, but anthrone rhubarb acid, the transformation product of intestinal bacteria, has cathartic activity, which can reduce the absorption of sodium and chloride ions in the colon and increase the secretion of potassium ions.Prostaglandins play an important role in the cathartic activity of anthracone.
(6) anti-inflammatory effect
The 1, 8-diacetylated rhubarb acid has been used to treat osteoarthritis.In the intestine, the acetyl groups of 1,8 -- diacetyl rhein (1,8 -- Diacelyrhein) can be completely hydrolyzed off in the form of rhubarb acid.
(7) treatment of diabetic nephropathy