High Purity API Triclabendazole Powder with Factory Price CAS 68786 -66-3

China High Purity API Triclabendazole Powder with Factory Price CAS 68786-66-3, Find details about China Triclabendazole, 68786-66-3 from High Purity API Triclabendazole Powder with Factory Price CAS 68786-66-3

Basic Info.

Model NO.

68786-66-3

Wickr

Bellachen

Common Name

Triclabendazole

CAS Number

68786-66-3

Molecular Weight

359.658

Boiling Point

495.9±55.0 °c at 760 Mmhg

Melting Point

175-176°c

Flash Point

253.7±31.5 °c

Molecular Formula

C14h9cl3n2OS

Density

1.6±0.1 g/cm3

Trademark

Hanhong

Transport Package

Customized

Specification

Customized

Origin

China

Model NO.

68786-66-3

Wickr

Bellachen

Common Name

Triclabendazole

CAS Number

68786-66-3

Molecular Weight

359.658

Boiling Point

495.9±55.0 °c at 760 Mmhg

Melting Point

175-176°c

Flash Point

253.7±31.5 °c

Molecular Formula

C14h9cl3n2OS

Density

1.6±0.1 g/cm3

Trademark

Hanhong

Transport Package

Customized

Specification

Customized

Origin

China

Product Desciption

High Purity API Triclabendazole Powder with Factory Price CAS 68786-66-3

Triclabendazole Biological Activity

Description	Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm [1]. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines [2].Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluating the relative acitvity of Triclabendazole [3].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Infection

Description

Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm [1]. Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines [2].Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluating the relative acitvity of Triclabendazole [3].

Related Catalog

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

Research Areas >> Infection

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	495.9±55.0 °C at 760 mmHg
Melting Point	175-176°C
Molecular Formula	C₁₄H₉Cl₃N₂OS
Molecular Weight	359.658
Flash Point	253.7±31.5 °C
Exact Mass	357.950104
PSA	63.21000
LogP	5.97
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.724
Stability	Stability