Product Name:Tacrolimus


 

Uses: 

For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.

Description :

Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.

Wuhan Vanz Pharm Inc., which is specialized in custom synthesis and R&D, is located in Wuhan, China. our main products are indacaterol, carmoterol etc. We have established long-term cooperation with Shanghai Institute of Organic Chemistry, WuhanUniversity etc. As a special team in organic chemistry and medicinal chemistry, we support the technology of R&D on new product.We have strong advantages on the process research and product R&D, pay attention to researching and developing new technologywhich is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus.We have completed R&D of more than 20 APIs and intermediates after the company founded.

R&D
Our R&D center covers an area of 1000 square meters, with four synthesis labs, one scale-up pilot labs and one analytical lab. Thelab is equipped with complete laboratory facilities and equipment. We have a professional research team of highly qualified andexperienced chemists. most of our R&D team are Master and higher. With their effort, we quickly transfer the science fruit intoproduction. Our manufacturing site is located in Wuhan which is equipped with 100L~5000L reactors; we can offer one-stop services from R&D to commercial production. (Normal reaction/ High-pressure reaction/ Catalytic reaction/ Low-Temperature reaction)