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Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3

China Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3, Find details about China Tacrolimus Monohydrate, Tacrolimus 0.1% Ointment from Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3

Model NO.
TGY201906130702
Product Name
Tacrolimus
Appearance
White Powder
CAS No.
104987-11-3
Molecular Formula
C44h69no12
Molecular Weight
804.02
Assay
99%
Coa
Available
Sample
Available
MOQ
Any Quantitiy
Service
OEM
Grade
Pharmaceutical Grade
Test Method
USP;GMP
Storage
Cool Dry Area
Shelf Life
24 Months Properly
Certificate
ISO9001:2008
Trademark
TGY
Transport Package
Boil Bag
Specification
HPLC 99%
Origin
Xi′an, Shaanxi, China (Mainland)
HS Code
29225090
Model NO.
TGY201906130702
Product Name
Tacrolimus
Appearance
White Powder
CAS No.
104987-11-3
Molecular Formula
C44h69no12
Molecular Weight
804.02
Assay
99%
Coa
Available
Sample
Available
MOQ
Any Quantitiy
Service
OEM
Grade
Pharmaceutical Grade
Test Method
USP;GMP
Storage
Cool Dry Area
Shelf Life
24 Months Properly
Certificate
ISO9001:2008
Trademark
TGY
Transport Package
Boil Bag
Specification
HPLC 99%
Origin
Xi′an, Shaanxi, China (Mainland)
HS Code
29225090

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Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3
 

 

Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3
 

Tacrolimus Basic information
Product Name:Tacrolimus
Synonyms:

(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,

19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-

methoxycyclohexyl)-1;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-

1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-

hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-

methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, 

[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,

19S*,26aR*]]-;L 679934;Protopic;FK-506:FR-900506;Fujimycin Prozraf

CAS:104987-11-3
MF:C44H69NO12
MW:804.02
EINECS:1308068-626-2
Product Categories:

Active Pharmaceutical Ingredients;Immunosuppressant.;Intermediates & 

Fine Chemicals;Pharmaceuticals;API;Chiral Reagents;Fujimycin, Prograf;

antibiotic;Inhibitors

Mol File:104987-11-3.mol
Tacrolimus Chemical Properties
Melting point 113-115°C
Fp 2ºC
storage temp. −20°C
solubility DMSO: >3 mg/mL
form solid
color white
CAS DataBase Reference104987-11-3(CAS DataBase Reference)

 

 

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug.It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
 

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Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3
 

1. Tacrolimus is used with other medications to prevent rejection of a kidney, heart, or liver transplant.
2. Tacrolimus is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. 
3. Tacrolimus can be combined with steroids, azathioprine (Imuran Azasan) or mycophenolate mofetil (CellCept).
Factory Anti-Inflammatory Drug Tacrolimus CAS104987-11-3

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