Cefotaxime Sodium 1 g Powder for Injection.

Therapeutic indications
Cefotaxime Sodium for Injection is indicated in the treatment of the following infections either before the infecting organism has been identified or when caused by bacteria of established sensitivity:
·Septicaemia.
·Respiratory tract infections: acute and chronic bronchitis, bacterial pneumonia, infected bronchiectasis, lung abscess and post-operative chest infections.
·Urinary tract infections: acute and chronic pyelonephritis, cystitis and asymptomatic bacteriuria.
·Soft tissue infections: cellulitis, peritonitis and wound infections.
·Bone and joint infections: osteomyelitis, septic arthritis.
·Obstetric and gynaecological infections: pelvic inflammatory disease.
·Gonorrhoea: particularly if penicillin-resistant.
·Other bacterial infections: meningitis and other sensitive infections suitable for parenteral antibiotic therapy.
·The administration of DBL Cefotaxime Sodium for Injection prophylactically may reduce the incidence of certain post-operative infections in patients undergoing surgical
Dose and method of administration
Intravenous (IV) and intramuscular (IM) administration
Dissolve DBL Cefotaxime Sodium for Injection in water for injections as shown below. Shake well until dissolved and then withdraw the entire contents of the vial into the syringe and use immediately.
Dose
The dosage, route of administration and dosage interval will depend on the site and severity of the infection, sensitivity of the pathogens and condition of the patient.
Adults
Urinary tract infections
The recommended dose is 2 g daily in two divided doses.
Other infections
For other infections the minimum recommended dosage is 2 g daily in divided doses. This dosage may be increased to 3, 4 or 6 g daily according to the severity of the infection, sensitivity of causative organisms and condition of the patient.
Prevention of post-operative infection
Cefotaxime Sodium for Injection should be administered immediately prior to surgery. A single dose of 1g is suitable for most procedures. For procedures longer than 4 hours a dose of 2 g is recommended. A single 1 g dose in combination with 500 mg metronidazole is effective in colorectal surgery
Gonorrhoea
Uncomplicated gonorrhoea due to non beta-lactamase producing organisms: One single intramuscular dose of 1 g.

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