China Offer OEM Nootropics CAS 191217-81-9 Pramipexole Powder, Find details about China Pramipexole, Pramipexole HCl from Offer OEM Nootropics CAS 191217-81-9 Pramipexole Powder
Offer OEM Nootropics CAS 191217-81-9 Pramipexole Powder | |
Product name | Pramipexole Dihydrochloride |
CAS NO. | 191217-81-9 |
Synonyms | Pramipexole dihydrochloride |
Category | Pharmaceutical Raw Materials, Active Pharmaceutical Ingredients, Bulk Drugs, Fine Chemicals. |
Purity | 99% Pramipexole dihydrochloride |
Appearance | Pramipexole dihydrochloride powder |
Shelf life | 2 years for Pramipexole dihydrochloride |
What is Pramipexole ?
Pramipexole dihydrochloride is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) andrestless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in bipolar disorder. It is also being investigated for the treatment of clinical depression and fibromyalgia.intermediate of pramipexole dihydrochloride monohydrate.
1. Pramipexole is used alone or with other medications to treat Parkinson's disease. It can improve your ability to move and decrease shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome").
2. Pramipexole is also used to treat a certain medical condition (restless legs syndrome - RLS) that causes an unusual urge to move the legs. Symptoms usually occur at night along with uncomfortable/unpleasant feelings in the legs. This medication can decrease these symptoms and thereby improve sleep.
Test Items | Standard | Test Results |
Character | Off-white to White Crystalline powder | Off-White Crystalline powder |
Solubility | Soluble in Water and Methanol, slightly soluble in Ethanol (96%), Almost insoluble in Dichloromethane | Complies
|
Identification | (1)Specific Rotation -67~-69.5°(on anhydrate basis) (2)IR: Meets the requirement. (3) Optical purity Test (4)Chloride Reaction | -68.8 Complies Complies Complies |
Clarity | Clear, not deeper than Y6. | Complies |
PH | 2.8~3.4 | 3.15 |
Related Substances | Impurity A≤0.15% Impurity B≤0.15% Impurity C≤0.15% Unknown single impurity≤0.1% Total Impurity≤0.5% | Not detected 0.04% Not detected 0.05% 0.16% |
Impurity D | Impurity D≤0. 5% | 0.1% |
Water | 4.5%~6.5% | 4.9% |
Heavy metals | ≤10ppm | Complies |
Sulfate Ash | ≤0.1% | 0.05% |
Assay (on anhydrate basis) | 99.0%~101.0% | 99.8% |