Pharmaceutical Intermediate Raw Powder Agomelatine / S20098 CAS 138112-76-2 From China

Pharmaceutical Intermediate Raw Powder Agomelatine / S20098 CAS 138112-76-2 From China, Find details about China Agomelatine, Agomelatine Price from Pharmaceutical Intermediate Raw Powder Agomelatine / S20098 CAS 138112-76-2 From China

Basic Info.

Model NO.

PX-A

CAS

52-24-4

Sample

Free

Usage

API

Product Nane

Agomelatine

Colour

White

Appearance

White Powder

Supply

Bulk

Trademark

OEM

Transport Package

25kg/Drum

Specification

25KG/Bag

Origin

China

HS Code

3001200010

Model NO.

PX-A

CAS

52-24-4

Sample

Free

Usage

API

Product Nane

Agomelatine

Colour

White

Appearance

White Powder

Supply

Bulk

Trademark

OEM

Transport Package

25kg/Drum

Specification

25KG/Bag

Origin

China

HS Code

3001200010

Product Desciption

Pharmaceutical Intermediate Raw Powder Agomelatine / S20098 CAS 138112-76-2 From China

Pharmaceutical Intermediate Raw Powder Agomelatine / S20098 CAS 138112-76-2 From China

Product name	Agomelatine
CAS No.	138112-76-2
Molecular Formula	C15H17NO2
Molecular weight	243.30098
Purity	99%
Grade Standard	Medicine Grade

Agomelatine is the world's first melatonin receptor MT1 and MT2 agonist antidepressant. It was developed by the French company Servier and is suitable for the treatment of severe depressive episodes in adult patients. We know that melatonin is an endogenous neurohormone, which is secreted only by the anterior pituitary of the pineal gland at night, and acts on the melatonin receptors concentrated in the suprachiasmatic nucleus (SCN) of the hypothalamus. Participates in mediating the circadian rhythm of mammals. It is a well-known guardian of time in the body and corrects the biological clock regulated by the external circadian cycle. However, due to the high catabolism rate of melatonin in the body, its short half-life and poor selectivity for its receptor located in the SCN have limited its use in the treatment of circadian circadian rhythm disorders. Therefore, in order to overcome these shortcomings of melatonin, the researchers designed a series of melatonin analogs. Molecular model studies show that the indole ring of melatonin is the structural site for catabolism inactivation, so the indole ring becomes an ideal site for isosteric modification. The agomelatine developed by Servier is the biological (electronic) isostere analogue of melatonin. It replaces the indole ring with a nucleus, making it more metabolically stable than melatonin .