COMPOSITION:
Each 5 ml contains:
Phenoxymethylpenicilin potassium BP equivalent to Phcnoxymethylpenicilin 125mg.
[Indications]
Phcnoxymethylpenicilln is indicated in the treatment of mild to moderately severe infections due to microorganisms
whose susceptibility to penicilin G is within the range of serum levels common to this particular dosage form. Therapy
should be guided by bacteriologic studies (including susceptibility tests) and by clinical response.
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with
Phenoxymethylpenicilln during the acute stage.
Phenoxymelhylpenicilin is active mainly to the followings: Sireplococcal Infections (without bacteremia); Pneumococcal
Infeclions;Staphylococcal Infections Susceptible to Penicilin G; Fusospirochetosis (Mncent's Gingivitis and Pharyngitis);
Mcdical Conditions in Which Oral Penicilin Therapy Is Indicated as Prophylaxis.
[Contraindications]
A previous hypersensitivity reaction to any penicilin is a contraindication.
[Dosage and administration]
The usual dosage recommendations for adults and children 12 years and over are as follows:
Streptococcal Infections: Mild to moderately severe infections of the upper respiratory tract, including scarlet fever and
mild erysipelas; 200,000 to 500,000 units every 6 to 8 hours for 10 days.
Pneumococcal Infections: Mild to moderately severe infections of the respiratory tract, including otitis media: 400,000
to 500,000 units every 6 hours until the patient has been afebrile for at least 2 days.
Staphylococcal Infections: Mild infections of skin and soft tissue (culture and susceptibility tests should be performed):
400,000 to 500,000 units every 6 to 8 hours.
Fusospirochetosis (Vincent's Infection) of the Oropharynx: Mild to moderately severe infections:
400,000 to 500,000 units every 6 to 8 hours.
Prophylaxis in the Following Conditions: To prevent recurrence following rheumatic fever and/or chorea: 200,000 to
250,000 units twice daily on a continuing basis.
[Warnings and precautions]
Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Sxygen, intravenous steroids,
and airway management, including intubation, should also be administrated as indicated.
Pseudomembranous colitis has been reported with nearly all antibacterial agents including penicillns, and may range in
severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with
diarrhea subsequent to the administration of antibacterial agents.
Penicillin should be used with caution in individuals with histories of significant allergies and/or asthma.
The oral route of administration should not be relied upon in patients with severe illness or with nausea, vomiting, gastric
dilatation, cardiospasm, or intestinal hypermotility.
Occasional patients will not absorb therapeutic amounts of orally administered penicillin.
In streptococcal infections, therapy must be sufficient to eliminate the organism (a minimum of 10 days); otherwise, the
sequelae of streptococcal disease may occur. Cultures should be taken following completion of treatment to determine
whether streptococci have been eradicated.
Prolonged use of antibiotics may promote the overgrowth of nonsusceptible organisms, including fungi.
If superinfection occurs, appropriate measures should be taken
Storage instructions:
Store below 25 degrees celsius. Protect from moisture. Keep out of reach of children.
Validity: Three Years