Lincomycin Injection 600mg/2ml GMP Certificated Western Medicine

China Lincomycin Injection 600mg/2ml GMP Certificated Western Medicine, Find details about China Jiemycin, Linkomycyna from Lincomycin Injection 600mg/2ml GMP Certificated Western Medicine

Pharmaceutical Technology
Chemical Synthesis
Standard
Bp/USP
Storage
Protect From Light.
Packaging
5/Ampoules/Box
Trademark
OEM
Specification
Lincomycin 600mg/2ml
Origin
China
Pharmaceutical Technology
Chemical Synthesis
Standard
Bp/USP
Storage
Protect From Light.
Packaging
5/Ampoules/Box
Trademark
OEM
Specification
Lincomycin 600mg/2ml
Origin
China
Product name: Lincomycin injection
Category: Liquid Injection 
Package: 600mg/2ml*5ampoules/box
Brand: OEM/GMP 
Packaging Details: As usual, we also can make as your requirement. 

indication
This product is suitable for sensitive staphylococcus, streptococcus, streptococcus pneumoniae and respiratory infections, skin and soft tissue infections caused by anaerobic bacteria, infection of female genital tract infection and pelvic and abdominal cavity infection, etc., the latter two diseases according to the situation of the product alone or with other joint application of antimicrobials.
In addition, patients with penicillin indications, such as patients allergic to penicillin or not suitable for penicillin, can be used as an alternative medicine.

adverse reactions
(1) gastrointestinal reaction: nausea, vomiting, abdominal pain, diarrhea and other symptoms;
Severe cases of abdominal cramps, abdominal tenderness, severe diarrhea (watery or abscess), accompanied by fever, abnormal thirst and fatigue (pseudomembranous enteritis);
Diarrhea, enteritis, and pseudomembranous enteritis can occur in the early stages of drug administration, and can occur weeks after stopping.
(2) blood system: occasionally leukocyte reduction, neutrophil reduction, neutrophils and thrombocytopenia are rare, and aplastic anemia is rare.
Visible
(3) an allergic reaction: rash, itching, etc., occasional urticaria, angioneurotic oedema and serum reaction, such as rare exfoliation, bulla dermatitis, erythema and S - J syndrome have been reported.
(4) there are occasional reports of jaundice using this product.
(5) low blood pressure, ecg changes and even heart rate and respiratory arrest can occur during quick drip injection.
(6) venous administration can cause thrombophlebitis.
contraindications
the patients who have a history of allergy to lincomycin and clindamycin are banned.

Notes
(1) allergic to this product may be allergic to clinicycin.
(2) interference with diagnosis: serum alanine aminotransferase and aspartate aminotransferase can increase after taking the drug.
(3) the following situations should be used with caution:
Bowel disease or previous history, especially ulcerative colitis, localized enteritis or antibiotics, enteritis (this product can cause pseudo - membranous enteritis).
The liver function decreased.
The renal function was severely impaired.
(4) pay close attention to the number of defecation during the use of drugs. If the number of defecation is increased, it should be noted that the possibility of pseudomembranous enteritis should be stopped and treated properly.
(5) to prevent the occurrence of acute rheumatic fever, the treatment of hemolytic streptococcal infection with this class of drugs is at least 10 days.
(6) treatment of pseudomembranous enteritis caused by this product may be restored after stopping the drug, and moderate to severe patients need to correct water and electrolyte disorders.
If there is no obvious improvement in the above treatment, oral metronidazole 250 ~ 500mg, 3 times a day.
If it can be treated with metronidazole, it can still be effective. If it is still ineffective, it can be taken orally by vancomycin (or methyvancomycin). Adult daily 0.5-2.0 g should be taken by 3 ~ 4 times.
(7) occasionally leading to overbreeding of unsensitive microorganisms or causing secondary infection, the corresponding measures should be taken once a double infection occurs.
(8) previous asthma or other allergy history should be used with caution.
(9) treatment of elderly persons, the liver, kidney function and blood routine should be examined regularly.
medication for pregnant and lactating women
This product can be concentrated in foetal liver after the placenta, although the human application fashion has no problem report, but in pregnant women application need to weigh the advantages and disadvantages.
This product can be secreted to the breast milk, the lactation woman should also be careful with, if must use, should pause lactation.
Children's medicine is not suitable for infants less than one month.
old age medication
Elderly people with serious underlying diseases can have adverse reactions such as diarrhea or pseudomembranous enteritis. They need to be closely observed when taking drugs.
drug interactions
1.It can enhance the neuromuscular blockage of inhaled anesthetics, resulting in skeletal muscle weakness and respiratory inhibition or paralysis (apnea), which should be noted during or after surgery.
Treatment with anticholinesterase or calcium salt is expected to be effective.
2.In combination with anti-peristaltic antidiarrheal and white clay antidiarrheal, this product may be caused by pseudo membranous enteritis associated with severe watery diarrhea during the course of treatment even after several weeks of treatment.
Because of the delayed discharge of the endotoxin in the colon, the diarrhea is prolonged and intensified. Therefore, it is not suitable for the anti-peristaltic therapy.
When combined with the use of white clay, the former will be significantly reduced, so both should be taken at the same time (at least 2 hours).
3.This product has neuromuscular blocking effect, which will lead to the reduction of skeletal muscle when combined with resistance to muscle weakness.
In order to control the symptoms of myasthenia gravis, the dosage of the anti-muscle medicine should be adjusted when used in combination.
4.Chloramphenicol or erythromycin on targeted replacement of this product, or obstruct the latter with the combination of bacterial ribosomal 50 s subunits in vitro experiments show clindamycin and erythromycin with antagonism effect, so the clindamycin unfavorable and chloramphenicol or erythromycin share.
5.And opioid share, this product of respiratory inhibition and opioid central respiratory inhibition can be lengthened by accumulative phenomenon has lead to respiratory depression or cause respiratory paralysis (apnea) may, therefore, must to closely observe the patient or guardian.
6.This product can enhance the function of neuromuscular blocker, which should be avoided.
7.In the same bottle static droplet with neonicycin and kanamycin is prohibited.
Drug overdose is mainly symptomatic therapy and supportive therapy, such as rehydration.
pharmacological toxicology
Pharmacological effects
The product of common aerobic gram positive bacteria have higher antimicrobial activity, such as staphylococcus aureus (including resistance to penicillin G), epidermis staphylococcus aureus, beta hemolytic streptococcus, streptococcus viridans and streptococcus pneumoniae.
There are good antibacterial effects on anaerobes including tetanus, bacillus diphtheria and bacillus.
There was no activity of gram-negative bacteria such as enterococcus, meningococcal, neisseria gonorrhoeae and haemophilus influenzae.
There was no cross resistance between this product and penicillin, chloramphenicol, cephalosporin and tetracycline, and some cross-resistance was found in the large ring lactone.
This product applies to the 50 s subunit ribosomal sensitive bacteria, prevent the extension of the peptide chain, thus inhibiting bacterial cell protein synthesis, general bacteriostatic agent, but at high concentration, on certain bacteria also has antiseptic effect.
Toxicology research
No such experiment was carried out and no reference was made.
pharmacokinetics
Adult intramuscular injection of 600 mg, 30 minutes of blood drug peak concentration (Cmax).
In addition to cerebrospinal fluid, it is widely and rapidly distributed in body fluids and tissues, including bone tissue.
The fetal circulation can be rapidly entered into the fetal circulation, and the concentration of the blood in fetal blood is 25%.
The protein binding rate was 77% ~ 82%.
This product is metabolized in liver, partial metabolite has antibacterial activity.
Blood elimination half-life (t1/2) was 4 ~ 6 hours, while the liver and renal function decreased, and t1/2 was extended to 10 ~ 20 hours.
This product can be excreted by biliary tract, kidney and intestinal tract, after intramuscular injection, 1.8% ~ 24.8% of the drug was excreted by urine, and the intravenous drip was followed by 4.9% ~ 30.3 %.
This product can also be secreted into milk.
Hemodialysis and peritoneal dialysis do not remove lincomycin.
Storage
sealed.

Lincomycin Injection 600mg/2ml GMP Certificated Western Medicine