China Decitabine CAS 2353-33-5 for Cancer White Powder 5-Aza-2-Deoxycytidine, Find details about China 2353-33-5, Decitabine from Decitabine CAS 2353-33-5 for Cancer White Powder 5-Aza-2-Deoxycytidine
Product Name: | 5-Aza-2'-deoxycytidine |
Synonyms: | 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one;5-Aza-2'-deoxycytidine,98+%;4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;Decitabine(NSC127716);4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-on;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-s-triazin-2(1h)-one;5-azadeoxycytidine;5-triazin-2(1h)-one,4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-3 |
CAS: | 2353-33-5 |
MF: | C8H12N4O4 |
MW: | 228.21 |
EINECS: | 219-089-4 |
Properties
Melting point | ~200 °C (dec.) |
alpha | D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water) |
Boiling point | 370.01°C (rough estimate) |
density | 1.3771 (rough estimate) |
refractive index | 1.6590 (estimate) |
storage temp. | −20°C |
solubility | acetic acid/water (1:1): 50 mg/mL |
pka | 14.02±0.60(Predicted) |
form | Powder |
color | White to Off-white |
Application
Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.
Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively
COA
Items Tested | Specification | Result |
Characters | White to off-white crystalline powder | Confirms |
Melting Point | 198-203 Degree | Confirms |
Assay (HPLC) | ≥99.00% | 99.51% |
Loss on Drying | Not more than1.0% | 0.21% |
Related substances | Not more than 1.0% | 0.11% |
The largest impurities | ≤0.3% | 0.09% |
Total impurities(HPLC) | ≤1.0% | 0.43% |
Total aerobic microbial | ≤100cfu/g | 59cfu/g |
Heavy Metal | ≤10ppm | conforms |
Staphylococcus aureus | Absence | Absence |
Pseudomonas aeruginosa | Absence | Absence |
Salmonella species | Absence | Absence |
Escherichia | Absence | Absence |