Factory Supply with Competitive Price CAS 33069-62-4 Paclitaxel  98%

Product Name:Paclitaxel
Other Name:taxol
Appearance:White or off-white crystalline powder
CAS:33069-62-4
MF:C47H51NO14
MW:853.91
Specification:99%
Melting Point:213°C-216°C 

Function

An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'.

When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane.

Application

Paclitaxel powder is a chemotherapy drug that is given as a treatment for some types of cancer.Paclitaxel powder is a mitotic inhibitor now used to treat patients with lung, ovarian, breast cancer,head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for theprevention of restenosis.

Paclitaxel powder works by interfering with normal microtubule breakdown during cell division.Together with docetaxel, it forms the drug category of the taxanes. paclitaxel powder was the subject of a notable total synthesis by Robert A. Holton.

As well as offering substantial improvement in patient care, paclitaxel has been a relatively

controversial drug. There was originally concern because of the environmental impact of its

original sourcing, no longer used, from the Pacific yew. The assignment of rights, and even the name itself, to BMS were the subject of public debate and Congressional hearings.

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