China Good Quality Repaglinide CAS 135062-02-1 as Antidiabetic, Find details about China Repaglinide, CAS 135062-02-1 from Good Quality Repaglinide CAS 135062-02-1 as Antidiabetic
Product Name: Repaglinide
Synonyms: (S)-(+)-2-Ethoxy-4-[[[N-[1-(2-piperidinophenyl)-3-methylbutyl]amino]carbonyl]methyl]benzoic acid;Benzoic acid, 2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)- 2-oxoethyl)-, (S)-;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxo-ethyl]benzoic acid;2-ethoxy-4-[2-keto-2-[[(1S)-3-methyl-1-(2-piperidinophenyl)butyl]amino]ethyl]benzoic acid;ag-ee388zw;Prandin, 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)butyl]amino]-2-oxoethyl]-benzoic Acid, AG-EE-623, Novonorm,;S(+)-2-Ethoxy-4-(2-oxo-2-((alpha-isobutyl-2-piperidinobenzyl)amino)ethyl)benzoesure
CAS: 135062-02-1
MF: C27H36N2O4
MW: 452.59
EINECS: 629-921-1
Melting point: 129-130.2 °C
Boiling point: 672.9±55.0 °C
Storage temp.: 2-8°C
Description:
Repaglinide was marketed in the US as an orally active hypoglycemic agent in patients with a type 2 diabetes mellitus, to lower blood glucose in synergistic combination with metformin, when hyperglycemia cannot be controlled by diet, exercise or metformin alone. Chiral (S)-repaglinide can be synthesized in several ways, each involving a stereoselective reduction of an imine or enamine group. Repaglinide is a nonsulfonylurea belonging to the meglitinide family, with an-releasing effect mediated by pancreatic betacells, by closing the ATP-sensitive K+ channels that, in turn, increases the cytosolic concentration of Ca++. In several animal models, repaglinide was more efficient than glibenclamide as a dose-dependant promoter of release, but its mechanism of action is probably slightly different. Repaglinide has a rapid onset of action, a short duration of action and a reduced risk of hypoglycemia compared to glyburide.
Usage:
Non-sulfonylurea oral hypoglycemic agent. Used as an antidiabetic
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Fiona Wei