Anti-Cancer Pharmaceutical Grade API 99% CAS 936563-96-1 Ibrutinib Powder
China Anti-Cancer Pharmaceutical Grade API 99% CAS 936563-96-1 Ibrutinib Powder, Find details about China Ibrutinib, Ibrutinib Powder from Anti-Cancer Pharmaceutical Grade API 99% CAS 936563-96-1 Ibrutinib Powder
Basic Info.
Model NO.
JL- Ibrutinib
Mf
C25h24n6o2
Appearance
White Powder
Application
Pharmaceutical Intermediates
Grade Standard
Medicine Grade
Sample
Avaliable
Certificate
GMP Coa ISO9001
Shelf Life
2 Years
Storage
Cool and Dry Place
Form
Powder
Trademark
JULONG
Transport Package
Foil Bag & Drum
Specification
98%
Origin
China
Model NO.
JL- Ibrutinib
Mf
C25h24n6o2
Appearance
White Powder
Application
Pharmaceutical Intermediates
Grade Standard
Medicine Grade
Sample
Avaliable
Certificate
GMP Coa ISO9001
Shelf Life
2 Years
Storage
Cool and Dry Place
Form
Powder
Trademark
JULONG
Transport Package
Foil Bag & Drum
Specification
98%
Origin
China
Product Desciption
Product Description
| Anti-cancer Pharmaceutical Grade API 99% CAS 936563-96-1 Ibrutinib Powder | ||||
| Product Name: | Ibrutinib | |||
| CAS No.: | 936563-96-1 | |||
| Purity | 99% | |||
| Appearance | Ibrutinib characteristic powder | |||
| Shelf life | 2 years | |||
| Usage | Ibrutinib is an active pharmaceutical ingredient used for antineoplastics | |||
| Storage | Ibrutinib should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. | |||
Ibrutinib, also known as PCI-32765, is a potent and orally active BTK inhibitor. Ibrutinib binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK.
Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm).
Application&Function:
PCI-32765 (Ibrutinib) is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nM for the purified Btk.PCI-32765(Ibrutinib) is highly active and well tolerated in CLL/SLL pts irrespective of high risk genomic abnormalities. Although follow-up is short, the high response rate and very low progression rate suggests that PCI-32765 (Ibrutinib) may be an important new targeted treatment approach for CLL pts. In ex vivo assays with whole bold, PCI-32765 (Ibrutinib) prevents the activation of human BCR with an IC50 of about 0.2 μM, while not influencing the activation of T cell.
Treatment of CD40 or BCR activated CLL cells with PCI-32765 (Ibrutinib) results in inhibition of BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765 (Ibrutinib) prevents activation-induced proliferation of CLL cells in vitro, and effectively inhibits survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement, and stromal cell contact. PCI-32765 is originally developed by Pharmacyclics. And participants is been invited for the phase I clinical trials.
Test Report
Items | Specifications | Results |
Appearance | White to whitish crystal powder | Conforms |
Loss on drying | NMT 0.5% | 0.33% |
Residue on ignition | NMT 0.1% | Conforms |
Heavy metal | NMT 20ppm | Conforms |
Assay (HPLC) | NLT 99.5% | 99.77% |
Related substances | NMT 0.5% | 0.23% |
Single impurity | NMT 0.1% | 0.07% |
Conclusion: Complies to the Enterprise standard | ||
1. Who are we?
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us?
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates
4. Why should you buy from us not from other suppliers?
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries
5. What services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,Western Union,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
Company Profile
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development
Package & Delivery & Payment Terms
Why Choose Us?
1. All inquiries will be replied within 12 hours.
Package & Delivery & Payment Terms
Why Choose Us?
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Contact Us
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