Hydroxypropyl-β-cyclodextrin has lower toxicity than parent cyclodextrin, non-toxic orally, and low hemolysis. A large number of animal experiments and clinical experiments have proved that it can be used for oral and injection. The US Food and Drug Administration It has been approved for use in food and medicine. The LD50 of general pharmaceutical grade hydroxypropyl-β-cyclodextrin to white mice is greater than 2000mg/kg, 4400mg/kg per day orally, repeated 90-day toxicity experiments show that it has no effect on the health of white mice. The irritation experiments on the skin and eyes of experimental rabbits showed that there was no irritation to the skin and eyeballs of the test subjects. The sensitivity test showed that it was not allergenic to the skin of experimental pigs. Hydroxypropyl-β-cyclodextrin has been well tolerated in animal experiments such as rats, mice and dogs, especially when taken orally, only showing very limited toxicity of Chemicalbook. In a short-term experiment, the subject only produced very slight physiological changes, while in a relatively long-term (three-month) experiment, the subject had minor hematological changes, but no histopathological changes. During intravenous administration, histopathological changes were found in the lungs, liver and kidneys, but these changes are reversible and will recover quickly after stopping the drug, without adverse effects on the body. Carcinogenicity studies have shown that the incidence of tumors in the pancreas and intestines of experimental rats has increased, but this is considered to be a phenomenon unique to rats. Experiments on rats and rabbits show that hydroxypropyl-β-cyclodextrin has no effect on embryos. In clinical trials, the human body has a good tolerance to hydroxypropyl-β-cyclodextrin, and the main discomfort is diarrhea. Data shows that hydroxypropyl-β-cyclodextrin has no effect on human renal function.
In food manufacturing, it is mainly used to eliminate odors, improve the stability of flavors and pigments, and enhance emulsification and moisture resistance. To improve the taste of food, it is a good stabilizer and flavoring agent for the pharmaceutical, food and cosmetics manufacturing industry. In medicine, Chemicalbook can improve the solubility and bioavailability of drugs, increase the efficacy of drugs or reduce the dosage, adjust or control the release rate of drugs, reduce drug side effects, and enhance drug stability. It is mainly used in oral liquids and is safe. The highest degree.