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Ursolic acid (sometimes referred to as urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oic-acid), is a pentacyclic triterpene acid, used in cosmetics that is also capable of inhibiting various cancer cell types by inhibiting the STAT3 activation pathway, one of which includes human fibrosarcoma by reducing expression of matrix metalloproteinase-9 via glucocorticoid receptors. It may also decrease proliferation of cancer cells and induce apoptosis. Ursolic acid has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation.
Ursolic acid can serve as a starting material for synthesis of more potent bioactive derivatives, such as antitumor agents. It has been found to reduce muscle atrophy and to stimulate muscle growth in mice. Ursolic acid has potential use as a cardioprotective compound
Ursolic acid has been shown to increase the amount of muscle and brown fat and decrease white fat obesity and associated conditions when added to diets fed to mice. Under physiological concentrations, ursolic acid also induces eryptosis (the apoptosis-like suicidal cell death in defective red blood cells)
Loquat leaf extract Oleaceae plant privet (Ligustrum lucidum Ait.) Leaves or Rosaceae Loquat Eriobotrya japonica (Thunb.) Lindl. Leaves, the main ingredient of ursolic acid.
Loquat Leaf Extract is present in a natural plant triterpenoids, have a variety of biological effects of sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, lower blood sugar. 2011 found that it has anti-carcinogenic, anti-tumor promoters, induced F9 teratoma cells and anti-angiogenesis effect, low toxicity and is likely to become effective new anti-cancer drugs. And Ming Wusuo ursolic acid, ursolic acid, is triterpenoids. In addition, ursolic acid has significant antioxidant function, which is widely used as a pharmaceutical and cosmetic raw materials.
Ursolic acid is a kind of natural triterpenoids, which is helpful in sedating, anti-inflammatory, antibacterial, resistance to diabetes, tulcer, antitumor, reducing blood fat, enhancing immune.
Ursolic acid also has the function of obvious antioxidant, so it is widely used in medicine, cosmetics materials and food emulsifier.