1.It is a broad-spectrum antibiotic with activity against numerous gram-positive and gram-negative bacteria.
2.Given its broad spectrum of activity, cefotaxime is used for a variety of infections, including:
 Lower respiratory tract infections - e.g. pneumonia (most commonly caused by S. pneumoniae)
 Genitourinary system infections - urinary tract infections (e.g. E. coli, S. epidermidis, P. mirabilis) and cervical/urethral gonorrhea
Gynecologic infections - e.g. pelvic inflammatory disease, endometritis, and pelvic cellulitis
 Bacteremia/septicemia - secondary to Streptococcus spp., S. aureus, E. coli, and Klebsiella spp.
 Intra-abdominal infections - e.g. peritonitis
 Bone and joint infections - S. aureus, Streptococcus spp.
 CNS infections - e.g. meningitis/ventriculitis secondary to N. meningitidis, H. influenzae, S. pneumoniae
3.Although cefotaxime has demonstrated efficacy in these infections, it is not necessarily considered to be the first-line agent. In meningitis, cefotaxime crosses the blood-brain barrier better than cefuroxime.

Treatment of infections of lower respiratory tract including pneumonia, urinary tract, skin and skin structures, bone and joints; treatment of bacteremia/septicemia, CNS infections, intra-abdominal infections including peritonitis, gynecological infections including pelvic inflammatory disease, endometritis and pelvic cellulitis caused by susceptible strains of specific microorganisms; perioperative prophylaxis.