Basic Information

Description
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community .

The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis . In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains . This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.

Function
Used for pesticides and reagents for analysis.

Used as strong basic catalyst, ethoxylating agent and as reductant for organic synthesis, pharmaceutical synthesis, etc.

Used in medicine industry, such as phenylbutazone, methyldopa, hydrochloride, aminopterin, pyrimethamine, pifu ampicillin and so on.

 

FAQ

Q1. Have your Product Quality been Approved by the Third Party Lab?
A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 

Q2. Is there any discount?
A: Of course, for the larger quantity, we always support with better price for our further cooperation. 

Q3. What is your package?
A: Powder: PE bag, glass bottle or PTFE bottle for inner packing, and then into the aluminium foil bag for outer packing.
Liquid: glass bottle or PTFE bottle for inner packing, and then into the aluminium foil bag for outer packing.
Bulk order: Fiber drum or steel drum.

Q4. Will you provide the sample for testing the quality?
A: We'd like to offer free samples to our clients for the quality evaluation for most products, but the shipping cost is borne by clients.

Q5. What are the payment terms?
A: We can accept the T/T, Western Union, Money Gram, PayPal, Bitcoin etc.

Q6. How long does it take the goods to arrive?
A: It is depending on your location,
For the small order, please expect the 5-7 days by DHL, UPS, TNT, FEDEX, EMS and so on.
For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea.

Q7. How do you treat quality complaint?
A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC, TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss.