Glucuronolactone is a naturally occurring chemical produced by the metabolism of glucose in the human liver. It is an important structural component of nearly all connective tissues. Glucuronolactone is also found in many plant gums.

Glucuronolactone is rapidly absorbed and metabolised into non-toxic metabolites such as xylulose. In addition, humans may be able to use glucuronolactone as a precursor for ascorbic acid synthesis. According to "The Merck Index", it is also used as a detoxicant.

Glucuronolactone is a popular ingredient in energy drinks with claims that it detoxifies the body. Although levels of glucuronolactone in energy drinks can far exceed those found in the rest of the diet, the European Food Safety Authority (EFSA) has concluded that exposure to glucuronolactone from regular consumption of energy drinks is not a safety concern (No Observed Adverse Effect Level of glucuronolactone = 1,000mg/kg/day). A fatality was reported after intake of 1420 ml of an energy drink.

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