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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59- 46 -1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

China Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2, Find details about China 94-09-7, Benzocaine from Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

Model NO.
94-09-7
Wickr
Bellachen
Common Name
Benzocaine
CAS Number
94-09-7
Molecular Weight
165.189
Boiling Point
310.7±15.0 °c at 760 Mmhg
Melting Point
88-90 °c
Flash Point
164.2±17.9 °c
Molecular Formula
C9h11no2
Density
1.1±0.1 g/cm3
Trademark
Hanhong
Transport Package
Customized
Specification
Customized
Origin
China
Model NO.
94-09-7
Wickr
Bellachen
Common Name
Benzocaine
CAS Number
94-09-7
Molecular Weight
165.189
Boiling Point
310.7±15.0 °c at 760 Mmhg
Melting Point
88-90 °c
Flash Point
164.2±17.9 °c
Molecular Formula
C9h11no2
Density
1.1±0.1 g/cm3
Trademark
Hanhong
Transport Package
Customized
Specification
Customized
Origin
China

Product Information

Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

Benzocaine Biological Activity

DescriptionBenzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease
Target

IC50: 0.8 mM (Na+ channel)[1].

In VitroBenzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2].
In VivoA common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3].
References

[1]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302.

[2]. Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1163-70.

[3]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6.

 Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point310.7±15.0 °C at 760 mmHg
Melting Point88-90 °C
Molecular FormulaC9H11NO2
Molecular Weight165.189
Flash Point164.2±17.9 °C
Exact Mass165.078979
PSA52.32000
LogP1.95
Vapour Pressure0.0±0.7 mmHg at 25°C
Index of Refraction1.555
Storage condition0-6°C
StabilityStable. Combustible. Incompatible with strong oxidizing agents.

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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

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Top Quality 99% Purity Benzocaine Powder Benzocaine CAS 94-09-7/73-78-9/137-58-6/59-46-1/51-05-8/136-47-0/94-09-7/553-63-9/5413-05-8/79099-07-3/125541-22-2

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