China High Purity Lisinopril Raw Powder for Hypertension Treatment CAS 83915-83-7, Find details about China Lisinopril, CAS 83915-83-7 from High Purity Lisinopril Raw Powder for Hypertension Treatment CAS 83915-83-7
High Purity Lisinopril Raw Powder for Hypertension Treatment CAS 83915-83-7
Quick Detail:
Name:Lisinopril
EINECS:278-488-1
Molecular Formula:C21H31O5N3.2(H2O)
CAS Registry Number:83915-83-7
Appearance:White to Off-White Crystalline Powder
Molecular Weight:405.48794
Density:1.251 g/cm3
Boiling Point:666.4 °C at 760 mmHg
Melting Point:160 C (Decomposes)
Flash Point:356.9 °C
Storage Temperature:2-8°C
Refractive index:-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)
Solubility:Soluble Appearance:white solid
Transport Information: OTH
Hazard Symbols:UN NO.
Safety:Experimental reproductive effects reported. When heated to decomposition it emits toxic vapors of NO
Stability:Stable at normal temperatures and pressures.
Usage:An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril
COA:
Items | Test Standard | Results |
Characteristics | White or off-white crystalline powder | Conform |
Identification | IR Spectrum according with that of CRS | Conform |
Solubility | Soluble in water,sparingly soluble in methanol,practically insoluble in acetone and in anhydrous ethanol | Conform |
Specific Rotation | -43°~-47° | -43.3° |
Water | 8.0~9.5% | 8.27% |
Sulphated ash | ≤0.1% | 0.06% |
Residual solvent | Acetone:≤5000ppm | 118ppm |
Ethanol:≤5000ppm | 21ppm | |
Dichloromethane:≤600ppm | Not detectable | |
Hexane:≤290ppm | 4ppm | |
Related substance | Impurity A≤0.3% | <0.025% |
Impurity B≤0.3% | Not detectable | |
Impurity C≤0.3% | 0.07% | |
Impurity D≤0.3% | Not detectable | |
Impurity E≤0.3% | 0.03% | |
Impurity F≤0.3% | 0.01% | |
Unspecified impurities≤0.10% | 0.05% | |
Total impurities≤0.50% | 0.39% | |
Microbiological purity | Aerobian bacteria total:≤100CFU/g | 5CFU/g |
Yeast and mould:≤10CFU/g | <1CFU/g | |
Escherichia coli:Not allowed | Not detectable | |
Assay(on dried basis) | 98.5%~101.5% | 100.5% |
Conclusion | Conforms to the standard of EP7.0 |
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High Purity Lisinopril Raw Powder for Hypertension Treatment CAS 83915-83-7