CAS 906673 -24-3 Crisaborole

China CAS 906673-24-3 Crisaborole, Find details about China Crisaborole, 906673-24-3 from CAS 906673-24-3 Crisaborole

Basic Info.

Model NO.

TY-02AL

CAS No.

906673-24-3

Appearance

White Powder

Einecs

616-396-9

Assay

99%

Shelf

2 Years

Trademark

tongyon

Transport Package

25kg/Drum 1kg, 10kg, 100kg, 200kg

Specification

25kg/drum

Origin

China

Model NO.

TY-02AL

CAS No.

906673-24-3

Appearance

White Powder

Einecs

616-396-9

Assay

99%

Shelf

2 Years

Trademark

tongyon

Transport Package

25kg/Drum 1kg, 10kg, 100kg, 200kg

Specification

25kg/drum

Origin

China

Product Desciption

Product name	Crisaborole
CAS	906673-24-3
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Crisaborole
CAS:906673-24-3
MF:C14H10BNO3
MW:251
EINECS:
Mol File:906673-24-3.mol
Boiling point:425.9±55.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. room temp
form powder
pka7.00±0.20(Predicted)
color white to beige

CAS 906673-24-3 Crisaborole

Description
Crisaborole is a topically administered, boron-containing, anti-inflammatory compound that inhibits the phosphodiesterase-4 (PDE4) activity and thereby suppresses the cytokine release of TNFalpha, IL-12, IL-23 and other cytokines. PDE4 is an an enzyme that converts the intracellular second messenger 3'5'-cyclic adenosine monophosphate (cAMP) into the active metabolite adenosine monophosphate (AMP). By inhibiting PDE4 and thus increasing levels of cAMP, crisaborole controls inflammation. The use of boron chemistry enabled synthesis of a low-molecular-weight compound (251 daltons), thereby facilitating effective penetration of crisaborole through human skin. Crisaborole is in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis. Preliminary studies in children and adults demonstrated favorable efficacy and safety profiles. Crisaborole may represent an anti-inflammatory option that safely minimizes the symptoms and severity of AD and that can be used for both acute and long-term management.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

CAS 906673-24-3 Crisaborole