High-Purity Amlodipine Maleate Powder/Apis

China High-Purity Amlodipine Maleate Powder/Apis, Find details about China Amlodipine Maleate from High-Purity Amlodipine Maleate Powder/Apis

Basic Info.

Heavy Metal

Nmt 20ppm

Trademark

Simcere Pharmaceutical

Transport Package

20kg/Drum

Specification

CP2015,

Origin

China

Heavy Metal

Nmt 20ppm

Trademark

Simcere Pharmaceutical

Transport Package

20kg/Drum

Specification

CP2015,

Origin

China

Product Desciption

Product Application

Amlodipine Maleate is the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug response activity through inhibition of the p-glycoprotein efflux pump.

Specifications

Item		Specifications
Characters		An almost white or yellowish crystalline powder, odorless, bitterish.
Melting point		Should be melted and decomposed simultaneously at 169~175 ºC
Optical rotation		Should be in range of -0.10° to +0.10°
Residual solvent		Content of dichloromethane should be mo more than 0.06%
		Content of alcohol should be mo more than 0.5%
		Content of acetone should be mo more than 0.5%
Loss on Drying		Not more than 0.5%
Residdue on ignition		Not more than 0.2%
Heavy metals		Not more than 20pppm
Assay		Calculated on dry basis, content of amlodipine maleate should not be less than 98.5%