Factory Supply Intermediate Crisaborole CAS 906673 -24-3

China Factory Supply Intermediate Crisaborole CAS 906673-24-3, Find details about China 906673-24-3, CAS 906673-24-3 from Factory Supply Intermediate Crisaborole CAS 906673-24-3

Basic Info.

Model NO.

906673-24-3

Storage Condition

Store at Rt

Trademark

FOUSI

Transport Package

Aluminium Foil Bag

Specification

Origin

China

Model NO.

906673-24-3

Storage Condition

Store at Rt

Trademark

FOUSI

Transport Package

Aluminium Foil Bag

Specification

Origin

China

Product Desciption

Factory Supply Intermediate Crisaborole CAS 906673-24-3

Product Name:	Crisaborole
Synonyms:	4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzoni trile AN 2728;AN-2728, >=98%;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzoni trile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzoni trile
CAS:	906673-24-3
MF:	C14H10BNO3
MW:	251.05

Factory Supply Intermediate Crisaborole CAS 906673-24-3

Boiling point	425.9±55.0 °C(Predicted)
density	1.33±0.1 g/cm3(Predicted)
storage temp.	room temp
form	powder
pka	7.00±0.20(Predicted)
color	white to beige

Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by the USFDA for the treatment of mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.

Factory Supply Intermediate Crisaborole CAS 906673-24-3