CAS 169590-42-5 Celecoxib Powder

China CAS 169590-42-5 Celecoxib Powder, Find details about China Celecoxib, 169590-42-5 from CAS 169590-42-5 Celecoxib Powder

Basic Info.

Model NO.

TY-02AL

CAS

169590-42-5

Appearance

White Powder

Einecs

616-396-9

Assay

99%

Shelf

2 Years

Trademark

tongyon

Transport Package

25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg

Specification

25kg/drum

Origin

China

Model NO.

TY-02AL

CAS

169590-42-5

Appearance

White Powder

Einecs

616-396-9

Assay

99%

Shelf

2 Years

Trademark

tongyon

Transport Package

25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg

Specification

25kg/drum

Origin

China

Product Desciption

Product name	Celecoxib
CAS	169590-42-5
Appearance	white powder
Assay	99%
Storage	Cool and Protect from light

Product Name:Celecoxib
CAS:169590-42-5
MF:C17H14F3N3O2S
MW:381.37
EINECS:685-962-5
Mol File:169590-42-5.mol
Melting point:157-159°C
Boiling point:529.0±60.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility DMSO: >20mg/mL
pka9.68±0.10(Predicted)
form powder
color white to off-white
Water Solubility 7mg/L(25 ºC)

CAS 169590-42-5 Celecoxib Powder

Description
DescriptionCelecoxib is a nonsteroidal antiinflammatory drug (NSAID) first launched as Celebrex in the US for the treatment of symptoms in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Celecoxib belongs to a new class of 1, 5-diarylpyrazoles and can be synthesized by heat-promoted heterocyclization of a trifiuoro-l,3-dione with appropriate arylhydrazine. Celecoxib is a highly selective inhibitor of COX-2, the inducible form of cyclooxygenase expressed during inflammatory processes; it does not block the constitutive form COX-1, thus suppressing the gastric and intestinal toxicity of most non-selective NSAIDs. The potency ratio COX1/COX2 on purified human enzymes was about 400. In several in vivo models of acute and chronic inflammation, Celecoxib demonstrated potent antiinflammatory activity without affecting gastric or urinary prostaglandin PGE2. In several clinical studies performed with patients suffering from osteoarthritis or rheumatoid arthritis, Celecoxib was shown to be well tolerated and to relieve pain and inflammation more efficiently compared with other standard NSAIDs; the gastrointestinal safety profile was significantly better than that of other NSAIDs. Interestingly, Celecoxib was approved for another indication in patients with familial adenomatous polyposis (FAP). A six-month clinical trial demonstrated a 28% reduction in the number of colorectal polyps with Celecoxib, compared to a 5% reduction with placebo.
Chemical PropertiesWhite powder
Usesexpectorant, gastric stimulant, insecticide
UsesFor relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis
UsesA selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

CAS 169590-42-5 Celecoxib Powder