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Wuhan Hhd Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate for Colon Cancer

China Wuhan Hhd Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate for Colon Cancer, Find details about China Sorafenib, CAS 475207-59-1 from Wuhan Hhd Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate for Colon Cancer

Model NO.
Sorafenib
Color
White
Grade
Pharmaceutical Grade
Trademark
hhdpharm
Specification
10g, 50g, 200g, 1kg, 5kg
Origin
China
Model NO.
Sorafenib
Color
White
Grade
Pharmaceutical Grade
Trademark
hhdpharm
Specification
10g, 50g, 200g, 1kg, 5kg
Origin
China
Sorafenib tosylate
475207-59-1

Product Name: Sorafenib tosylate
Synonyms: SORAFENIB TOSYLATE;Sorafenib & its intermediates;Sorafinib mesylate;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;Sorafenib Tosylate(Bay 43-9006,Nexavar);SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE);BAY 43-9006;BAY43-9006;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)
CAS: 475207-59-1
MF: C28H24ClF3N4O6S
MW: 637.0265696
EINECS: 641-758-8

General Description:    

Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, VEGF-R, Kit, and Raf. Sorafenib is 39% to 48% bioavailable and CYP3A4-mediated metabolism giveseight identified metabolites including the N-oxide, which isequally active with the parent. However, the majority of thedrug in plasma is present as the parent compound.Sorafenib is highly protein bound (99.5%). The drug iseliminated primarily in the feces (77%) with 19% appearingin the urine as glucuronides (UGT1A1) and has a eliminationhalf-life of 24 to 48 hours. The most commonly seentoxicity is skin rash that normally occurs within the first6 weeks of therapy. Other adverse effects include hypertension,fatigue, increased wound healing time, and increasedrisk of bleeding.

Uses: An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.

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Only for Research & Lab Use,not for human use.
We also supply the following small molecule chemical compounds as follows:
Calcipotriol CAS No. 112965-21-6 with High Purity 99.0%Min. Small Molecule Compounds Psoriasis
Calcipotriol CAS No. 112965-21-6 with High Purity 99.0%Min. Small Molecule Compounds Psoriasis

Calcipotriol CAS No. 112965-21-6 with High Purity 99.0%Min. Small Molecule Compounds Psoriasis


 

Wuhan Hhd Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate for Colon Cancer

 

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