Levobupivacaine hydrochloride
CAS 27262-48-2
Melting point | 254 °C (dec.)(lit.) |
alpha | -12.5 º (c=2, water) |
storage temp. | 2-8°C |
solubility | H2O: soluble20mg/mL, clear |
form | powder |
color | white to beige |
optical activity | [α]/D -10 to -14°, c = 1.0 in H2O |
InChIKey | SIEYLFHKZGLBNX-NTISSMGPSA-N |
CAS DataBase Reference | 27262-48-2(CAS DataBase Reference) |
Hazard Codes | T+,Xn |
Risk Statements | 26/27/28-20/21/22-28 |
Safety Statements | 22-36/37/39-45-36/37-53 |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | TK6125000 |
Uses | (S)-(-)-Bupivacaine Hydrochloride is the salt analogue of a local anaesthetic used for epidural and intrathecal anaesthesia. |
Description | Levobupivacaine was first launched in the US for the production of local anesthesia for surgery and obstetrics and for post-operative pain management. It is the (S)-enantiomer of the long acting, highly potent local anesthetic bupivacaine (Marcaine) that can be prepared by a three step sequence from (S)-pipecolic acid or from (S)-lysine by oxidative deamination and stereospecific ring closure to (S)-pipecolamide core structure. Levobupivacaine exhibits its long-acting local anesthetic effect by blocking neuronal sodium channel ion flow in nerve axons. Clinical studies demonstrated an efficacy and a general profile closely resembling those of the racemic bupivacaine currently in use; however, it produced an enhanced safety profile, in particular substantially reduced (about one-third) cardiotoxicity (less effect on myocardial contractility and QT, prolongation) and CNS depressive side effects. Onset and duration of blockade were also equivalent or even better. |
Chemical Properties | white crystalline powder |
Uses | Local anesthetic; analgesic. |
Definition | ChEBI: The monohydrochloride salt of levobupivacaine. |
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Hanhong Pharmaceutical Co.,LID. provides high quality chemical raw materials, chemical auxiliaries and industrial chemicals fordomestic and foreign customers. All the products sold by hanhong pharmaceutical are produced in IS0 9001 certified factories andhave been passed the quality inspection by China entry-exit inspection and quarantine bureau with a 100% pass rate.HanhongPharmaceutical Co.,LTD. is a chemical group company integrating the production and sales of chemical products.The company hasten factories in Hubei,Jiangsu, Hebei and Shandong.The international branch of Hanhong pharmaceutical, with import and exportrights, specializes in high-quality chemical products. For many years, Qingdao cosco in line with the "QDOCEAN brand, build ahundred years of enterprise " business philosophy and "loyal dedication" spirit and style, formed a unique corporate culture, with astrong cohesion, execution and fighting capacity. In the next few years, the concern and support of a friend,QDOCEAN will continueto seize the favorable opportunity, promote the adjustment of structure, the idea of technology innovation "storage concentrated,incremental optimization ", improve the quality and the effective investment and development of high value-added chemical industry,medicine, chemical, biological chemical, construction of the grand goal of a comprehensive green circular economy industrial base.
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4. Purity and after-sales service;
5. Sample for testing.
1. How is the quality?
Above 99% purity.
2. Can I order sample for testing?
Yes, of course. Welcome your sample order before bulk order. We will send the samples directly to your door by express. The quality of sample will prove our ability and our products quality.
3. Do I need to pay extra for shipping cost?
Our price includes the shipping cost already.
4. What's your MOQ?
For the high value product, our MOQ stars from 10g, 100g and 1kg.
5. What kind of payment terms do you accept? T/T or L/C, D/P, D/A, WU, MG.
6. How about your delivery time?
Generally, it takes 3 business days after receiving your advance payment.
7. How do you treat quality complaint?
First, the incidents about quality problems are minimized by our company. However, if there exists a real quality problem caused by us, we will send you free goods for replacement or make up your loss.
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