China Sulfaguanidine 57-67-0/ Maduramycin Ammonium 84878-61-5/Fexofenadine HCl 153439-40-8/Tenofovir Disoproxil Fumarate 202138-50-9/Pidotimod CAS 121808-62-6, Find details about China Sulfaguanidine, Maduramycin Ammonium from Sulfaguanidine 57-67-0/ Maduramycin Ammonium 84878-61-5/Fexofenadine HCl 153439-40-8/Tenofovir Disoproxil Fumarate 202138-50-9/Pidotimod CAS 121808-62-6
Introduction
Name | Pidotimod |
Synonyms | (4R)-3-[[(2S)-5-Oxo-2-pyrrolidinyl]carbonyl]-4-Thiazolidinecarboxylic acid |
Brand | Faithful |
Molecular Formula | C9H12N2O4S |
Molecular Weight | 244.27 |
CAS Registry Number | 121808-62-6 |
Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are integral to communication with adaptive immunity cells. Pidotimod has also been shown to stimulate dendritic cells to release pro-inflammatory molecules such as MCP-1 and TNF-α cytokines, and to inhibit thymocyte apoptosis caused by a variety of apoptosis inducing molecules.
Pitidomod is mainly used in children with recurrent respiratory infections and urinary tract infections (urinary tract infections). It also has therapeutic effects on chronic bronchitis and viruses. Flu and viral herpes are effective. It can also be used for infections caused by Streptococcus pneumoniae and Escherichia coli, Green bacillus, Proteus.
Function
Pitidomod is mainly used in children with recurrent respiratory infections and urinary tract infections (urinary tract infections). It also has therapeutic effects on chronic bronchitis and viruses. Flu and viral herpes are effective. It can also be used for infections caused by Streptococcus pneumoniae and Escherichia coli, Green bacillus, Proteus.
Specification
Item | Standard | Test Results | |
Identification | A.H-NMR:Comply with the structure | Complies | |
B.LC-MS:Comply with the structure | Complies | ||
C.The IR spectrum of sample should be identical with that of reference standard; | Complies | ||
D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. | Complies | ||
Crystallinity | meets the requirements. | Complies | |
Loss on drying | ≤2.0% | 0.19% | |
Heavy metals | ≤10 ppm | <10ppm | |
Water | ≤1.0% | 0.1% | |
Sulphated ash | ≤0.5%, determined on 1.0 g. | 0.009% | |
Related substances | Unspecified impurities: for each impurity | ≤0.10% | <0.10% |
Total Impurity | ≤0.5% | 0.18% | |
Assay | 99.0%~101.0% (anhydrous substance). | 99.8% | |
Microbiological Analysis | |||
Total plate count | ≤1000cfu/g | Complies | |
Yeast and Moulds | ≤100cfu/g | Complies | |
E. Coli. | Absent | Negative | |
Salmonella | Absent | Negative | |
S.aureus | Absent | Negative | |
Storage | Preserve in well-closed, light-resistant and airtight containers. | Complies |