Basic Info.

Model NO.

HT197-2

Model NO.

HT197-2

Product Desciption

Trade name ribavirin buccal tablets

Generic name: ribavirin buccal tablets

The main ingredient of this product is ribavirin.

Indications are suitable for respiratory syncytial virus caused by viral pneumonia and bronchitis, cutaneous herpes virus infection, influenza and herpetic stomatitis.

Adverse reactions Common adverse reactions include anemia, fatigue, and so on, which disappear after drug withdrawal. Less common adverse reactions include fatigue, headache, insomnia, anorexia, nausea, vomiting, mild diarrhea, constipation, etc., and may cause the decrease of red blood cells, white blood cells and hemoglobin.

Contraindicated for allergy and pregnant women.

1. This product has strong teratogenic effect. The daily dose of 1mg/kg in rabbits can cause embryo damage, so it is forbidden to be used in pregnant women and women who are likely to become pregnant.

2. A small amount of drugs are excreted from milk, and are toxic to both mother and child and the second generation of animals. Therefore, breastfeeding women should stop breastfeeding during the medication period, and milk should also be discarded. This product is not intended for use in lactating women because RSV infection is self-limited.

3. Not recommended for the elderly.

Precautions 1. Use with caution in severe anemia and abnormal liver function.

2. Interference with diagnosis: oral administration of this product may increase blood bilirubin by up to 25%. Large doses can cause a decrease in hemoglobin content.

3. Take your medication as soon as possible. Respiratory syncytial virus pneumonia is generally effective when administered within the first 3 days. This product should not be used in patients without laboratory confirmed respiratory syncytial virus infection.

4. Long-term or large dosage has adverse reactions to liver function and blood image.

1. This product has strong teratogenic effect. The daily dose of 1mg/kg in rabbits will cause embryo damage, so it is forbidden to be used in pregnant women and women who are likely to become pregnant (this product is very slow to eliminate in the body, and can not be completely removed from the body 4 weeks after withdrawal). 2. A small amount of drugs are excreted from milk, and are toxic to both mother and child and the second generation of animals. Therefore, breastfeeding women should stop breastfeeding during the medication period, and milk should also be discarded. This product is not intended for use in lactating women because RSV infection is self-limited.

Use of drugs for children The use of drugs for children under 6 years of age is unclear.

Medication for the elderly is not recommended for the elderly.

Drug interaction It is antagonistic when used with zidovudine because it inhibits the conversion of zidovudine to the active form of zidovudine phosphate.

Excessive use of large doses of drugs can cause heart damage, respiratory diseases (chronic obstructive pulmonary disease or asthma) can cause breathing difficulties, chest pain, etc.

Drug toxicology 1. Pharmacological action: broad spectrum antivirals. It can inhibit the growth of respiratory syncytial virus, influenza virus, hepatitis A virus, adenovirus and other viruses in vitro, but its mechanism is not completely clear. This product does not change the virus adsorption, invasion and peeling, and does not induce interferon production. Drugs enter the cells infected by the virus rapidly phosphorylation and its product as competitive inhibitors of virus synthetase, inhibition of inosine monosodium phosphate dehydrogenase, influenza virus RNA polymerase and mRNA guanosine transferase, causing cell guanosine triphosphate, damage the virus RNA and protein synthesis, inhibition of viral replication and spread. Respiratory syncytial virus may also have an immune and neutralizing antibody effect.

2. Toxicological studies :(1) animal experiments have found that this product can induce benign tumors of breast, pancreas, pituitary gland and adrenal gland, but the carcinogenicity of human has not been confirmed. In animals such as hamsters, the drug can cause deformities of the head, palate, eyes, jaw, bone and gastrointestinal tract, and reduce the survival of offspring. However, primate experiments have not found any effect of the drug on the fetus.

(2) mice, rats and monkeys were given oral ribavirin at 30, 36 and 120mg/kg, respectively, for 4 + weeks (equivalent to human doses: 4.8, 12.3 and 111.4mg/kg for children weighing 5kg, or 2.5, 5.1 and 40mg/kg for adults weighing 60kg). The above are calculated according to body surface area), cardiac injury occurred.

The pharmacokinetics were rapidly absorbed by oral administration and the bioavailability (F) was about 45%. The peak plasma concentration (Cmax) was about 1 ~ 2mg/L 1.5 hours after oral administration. Barely binding to plasma proteins. The concentration of drugs in respiratory secretions was mostly higher than that in blood. Drugs can enter the red blood cells and accumulate in large quantities. After long-term drug use, the concentration of drug in cerebrospinal fluid can reach 67% of that in blood of the same period. This product can pass through the placenta and enter the milk. Metabolized in the liver. The half-life (T1/2) is about 0.5 ~ 2 hours. This product is mainly excreted through the kidney. The rate of urine excretion in 72 ~ 80 hours was 30% ~ 55%. The 72-hour fecal excretion rate was about 15%. Drugs can accumulate in red blood cells for several weeks.


FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.

4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.

5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese

Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages

Our Service
a)  Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.

Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.

Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.

At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.


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