Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine

China Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine, Find details about China Nsc 4688, Benzocaine (See B197952 for Labelled) from Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine

Model NO.
Benzocaine
Trademark
xingjiu
Transport Package
Bags/ Drums
Specification
99%
Origin
Chain
Model NO.
Benzocaine
Trademark
xingjiu
Transport Package
Bags/ Drums
Specification
99%
Origin
Chain
Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine



 Benzocaine Basic information
 
Product Name:Benzocaine
Synonyms:NSC 4688;Benzocaine (See B197952 for Labelled);Benzocaine, USP, EP;Ethyl 4-aMinobenzoate, 98% 100GR;Ethyl 4-aMinobenzoate, 98% 500GR;(p-(Ethoxycarbonyl)phenylaMine;4-(Ethoxycarbonyl)phenylaMine;4-Aminobenzoic Acid Ethyl Ester Benzocaine
CAS:94-09-7
MF:C9H11NO2
MW:165.19
EINECS:202-303-5
Product Categories:C8 to C9;Carbonyl Compounds;Aromatic Esters;Esters;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceutical intermediate;API;Pharma materials;Intermediate of Tetracaine hydrochloride;medical intermediate;Benzocaine;organic interme;Pharmaceuticals;Research Chemical
 
 

 

 Benzocaine Chemical Properties
 
 
Melting point 88-90 °C
Boiling point 172 °C (12.7517 mmHg)
density 1.17
refractive index 1.5600 (estimate)
Fp 172°C/13mm
storage temp. 2-8°C
solubility alcohol: soluble1 gm in 5 ml
pka2.5(at 25ºC)
form Crystalline Powder
color White
Water Solubility Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water
Merck 14,1086
BRN 638434
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKeyBLFLLBZGZJTVJG-UHFFFAOYSA-N
CAS DataBase Reference94-09-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzoic acid, 4-amino-, ethyl ester(94-09-7)
EPA Substance Registry SystemBenzocaine (94-09-7)
 


Benzocaine  Description
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.




Benzocaine  Uses
1.    Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied in any form it temporarily numbs or blocks the nerve endings, which leads to a decreases in the amount of pain. It is used in cattle, sheep, swine and horses for local and prolonged low epidural anaesthesia. Standard therapeutic doses of benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and ulcerated surfaces in horses, cattle and sheep applied twice a day until healing.
2.    A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
Anesthetic;Na+ channel blocker
3.     Benzocaine acts on the central nervous system, cardiovascular system, neuromuscular junctions and ganglion synapse. Its mechanism of action is to prevent the generation and conduction of the nerve impulse. Local anaesthetics block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action of local anaesthetics is due to their direct interaction with voltage-sensitive Na+ channels. 4.    4.  4.    Benzocaine is mainly hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the action of sulphonamides.
5.      Benzocaine is distributed in the body, crosses the placenta and is metabolised in the liver and in the plasma by non-specific cholinesterases. Benzocaine and its main metabolite (para-aminobenzoic acid) are excreted into urine.
6.       Benzocaine appears as a moderately toxic compound after single administration. The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may induce methemoglobinemia in several species such as sheep, cats and dogs.



Benzocaine  Chemical Properties
white odourless crystals


Benzocaine  Fuction
1.   Benzocaine is used as an anesthetic
2.  Local and topical anesthetic used in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
3.   Apply to a maximum of three to four times a day to the affected area, as directed by the physician.




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Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine




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Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine

Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine

Packing and Shipping

1. Powder package
    1kg ---Aluminum foil bag  
5-10kg ---Carton box    
   25kg --- Kraft paper bag/ drum 

2. Liquid package
         1L ----- Fluorinated Bottle       
20L-25L -----Plastic drum /fiber drum 


Related to Anesthesia Purity 99% CAS 94-09-7 BenzocaineRelated to Anesthesia Purity 99% CAS 94-09-7 Benzocaine

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Related to Anesthesia Purity 99% CAS 94-09-7 Benzocaine


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