China Sonwu Supply CAS 1038915-60-4 Anti-Cancer Niraparib Tosylate Mk4827, Find details about China Niraparib Tosylate, Mk4827 from Sonwu Supply CAS 1038915-60-4 Anti-Cancer Niraparib Tosylate Mk4827
Name | Sonwu Supply CAS 1038915-60-4 Anti-Cancer Niraparib Tosylate MK4827 |
CAS NO. | 1038915-60-4 |
Molecular Formula | C19H20N4O |
MW | 320.3883 |
Purity | 99% |
Appearanc | White powder |
Certificate | ISO, SGS, GMP, HACCP |
MOQ | 10 g |
Shelf life | 2 Years |
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide is also known as MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.
Niraparib is an orally active small molecule PARP inhibitor developed by Tesaro to treat ovarian cancer.The drug is approved by the US FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy.
You may interested in:
Other Hot-Selling Similar Product | |||
Gefitinib | Lapatinib | AZD9291 | Lapatinib ditosylate |
Dasatinib | Imatinib | Ibrutinib | Niraparib tosylate monohydrate |
LOXO 195 | LOXO 101 | Fluconazole | Cabozantinib Malate |
baricitinib | ketoconazole | Imatinib mesylate | Erlotinib Hydrochloride |