Pharmaceutical Intermediate 99% Purity Rad 140 / Rad-140 / Radarol Raw Powder 118237-47-0 Testolone

China Pharmaceutical Intermediate 99% Purity Rad 140 / Rad-140 / Radarol Raw Powder 118237-47-0 Testolone, Find details about China S4 Powder Andarin S-4 401900-40-1, Mk/2866 CAS 841205-47-8 from Pharmaceutical Intermediate 99% Purity Rad 140 / Rad-140 / Radarol Raw Powder 118237-47-0 Testolone

Trademark
non
Transport Package
Caplets
Specification
10mg
Origin
China
Trademark
non
Transport Package
Caplets
Specification
10mg
Origin
China

Pharmaceutical Intermediate 99% Purity Rad 140 / Rad-140 / Radarol Raw Powder 118237-47-0 Testolone



We can do OEM as your inquiry(Ingredients, dosage, packaging, logo)
 
Synonyms
sr9011
MOQ
10G
CAS No.
1379686-29-9
Appearance
White powder
Molecular Formula
C23H31ClN4O3S
Assay
≥99.0%
Application
Pharma grade or research purpose
Packing
As per your request
Storage
Preserve in tight,light-resistant containers in a cool place
Remarks
NA
Custom synthesis
Available
Supply Ability
10kg/month
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
 
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