China High Quality Medicine Grade API CAS 7361-61-7 Xylazine, Find details about China 7361-61-7 Xylazine, Powder Xylazine from High Quality Medicine Grade API CAS 7361-61-7 Xylazine
Xylazine Chemical Properties |
Melting point | 140 C |
Boiling point | 334.2±52.0 °C(Predicted) |
density | 1.0905 (rough estimate) |
refractive index | 1.5700 (estimate) |
storage temp. | -20°C |
solubility | Soluble in at 50mg/ml. Also soluble in dilute acid solutions. |
pka | 7.67±0.20(Predicted) |
CAS DataBase Reference | 7361-61-7(CAS DataBase Reference) |
Safety Information |
Hazard Codes | T,Xi |
Risk Statements | 25-36/37/38 |
Safety Statements | 45-37/39-26 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | XJ0776300 |
HazardClass | 6.1 |
HS Code | 2934990002 |
Toxicity | LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner) |
MSDS Information |
Provider | Language |
---|---|
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine | English |
SigmaAldrich | English |
Xylazine Usage And Synthesis |
Originator | Xylazine,Bayer |
Uses | Antinociceptive;Alpha-2 adrenergic agonist |
Manufacturing Process | 2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with , were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical). |
Therapeutic Function | Analgesic, Anesthetic |
Safety Profile | Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx. |
Xylazine Preparation Products And Raw materials |
Raw materials | 3-Aminopropanol-->-->--> |