Description
The combination of tylosin and doxycycline acts additively. Doxycycline belongs to the group of tetracyclines and acts bacteriostatically against many Gram-positive and Gram-negative bacteria like Bordetella, Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Doxycycline is also active against Chlamydia, Mycoplasma and Rickettsia spp. The action of doxycycline is based on inhibition of bacterial protein synthesis. Doxycycline has great affinity towards the lungs and is therefore especially useful for treatment of bacterial respiratory infections. Tylosin is a macrolide antibiotic with bacteriostatic action against mainly Gram-positive bacteria like Campylobacter, Mycoplasma, Pasteurella, Staphylococcus, Streptococcus and Treponema spp.

Composition
Contains per gram powder:
Doxycycline hyclate     100 mg.
Tylosin tartrate     100 mg.
Carrier ad     1 g.

 

Indications
Gastrointestinal and respiratory infections caused by tylosin and doxycycline sensitive micro-organisms like Bordetella, Campylobacter, Chlamydia, E. coli, Haemophilus, Mycoplasma, Pasteurella, Rickettsia, Salmonella, Staphylococcus, Streptococcus and Treponema spp. in calves, goats, poultry, sheep and swine.

Contra indications
Hypersensitivity to tetracyclines and/or tylosin.
Administration to animals with a seriously impaired hepatic function.
Concurrent administration of penicillines, cephalosporines, quinolones and cycloserine.
Administration to animals with an active microbial digestion.


Side effects
Discoloration of teeth in young animals.
Hypersensitivity reactions.
Diarrhoea can occur.

Dosage
For oral administration
Calves, goats and sheep : Twice daily, 5 gram per 100 kg body weight for 3 - 5 days.
Poultry and swine    :    1 kg per 1000 - 2000 litre drinking water for 3 - 5 days.