Chinese Name: L- prolyl
Chinese Synonyms: L- prolyl amide; L-- prolyl amide; L prolyl amide; L- proline amide; L- prolyl ammonia; (S) - prolyl ammonia; L- (-) - prolyl amide, 99%; L- prolyl amide (white crystal).
English Name: L-Prolinamide
English synonyms are: PROLINE-NH2; PROLINAMIDE; (S) -PYRROLIDINE-2-CARBOXYLIC ACID AMIDE; (S) -PROLINAMIDE; H-PRO-NH2; L-PROLINE AMIDE; and H-PRO-NH2 (-);
CAS: 7531-52-4
Molecular formula: C5H10N2O                              
Molecular weight: 114.15
EINECS: 231-397-0
Related categories: AMINOACIDS DERIVATIVES; APIs Amino; Acids; amino acid; Proline P]; Amino [Pro, Acids and Derivatives; Amides (Chiral); Chiral Building Blocks; Synthetic Organic Chemistry; amino acid esters; Amino Acid Derivatives; Peptide Synthesis; Proline Miscellaneous; protection amino acids; Reagents; Aromatics; Catalyst; Heterocycles; amino acids and derivatives; API; chemical biology; amino acids; pharmaceutical intermediates; pyrrolidine; Vinda gliptin intermediates; other biochemical reagents; amino acids; non natural amino acids; Pharmaceuticalintermediates; intermediates; pharmaceutical raw materials; natural amino acid and its derivatives; Vinda Palladium Catalysis 4 intermediates; palladium catalyst; amino acids and derivatives; amino acids; organic materials; amino acid derivatives
Mol file: 7531-52-4.mol

 

 

 

 

 

 

 

 

 

L-prolinamide is the intermediate of Vildagliptin, Vildagliptin (previously LAF237, trade names Galvus, Zomelis,) is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus.

 

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