We are the most professional real "MANUFACTURER" and "SUPPLIER" of CHOLIC ACID series materials on MIC, welcome the enquiry from both Foreign and Domestic customers.

We can provide:

(1) Cholic Acid (Free Grade 50%)                                                             CAS #:81-25-94

(2) Cholic Acid (Food Grade 90%)                                                            CAS #:81-25-94

(3) Cholic Acid (Pharmaceutical Grade 95%;98%)                                CAS #:81-25-94

(4) Chenodeoxycholic Acid(intermediate of Ursodeoxycholic Acid)      CAS #:474-25-9

(5) 3alpha-Hydroxy-7-oxo-5beta-cholic acid(7K-LCA)                           CAS #:4651-67-6

(6) Ursodeoxycholic Acid(EP9/USP/IP GRADE WITH GMP)               CAS #:128-13-2  

(7)Tauroursodeoxycholic acid   EP9                                                           CAS #:14605-22-2
(8)Obeticholic Acid  (OBCA)  98%/99%                                                   CAS #:459789-99-2
(9)Obeticholic Acid Intermediate-1(OB N-1)                                            CAS #:915038-26-5
(10)Obeticholic Acid Intermediate-2(OB N-2)                                          CAS #:1516887-33-4
(11)Obeticholic Acid Intermediate-3(OB M-2)                                          CAS#:1352328-66-5
 

Description:

Product Name:Chenodeoxycholic Acid

CAS:474-25-9
Molecular Formula: C₂₄H₄₀04
Molecular Mass:392.58
[Appearance]: white crystal powder, no foreign substance, no obvious odor
[Melting Point]: 197~202.0ºC
[Loss on Dry]: ≤1.0%
[Residue on Ignition]: ≤0.1%
[Heavy Metal ]: ≤10ppm
[Assay Determination]: 98.0%~101.0% (dries basis)
[Related Substance]:the single impurity≤0.1%, total impurities≤2.0%
[Package and Storage Condition]: 25kg/drum, store and seal away from light
 

What is Chenodeoxycholic acid(CDCA)?
Chenodeoxycholic acid (CDCA; also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids.It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name .

Indication

Chenodeoxycholic acid is a bile acid. Bile acids are steroid acids found predominantly in the bile of mammals. The distinction between different bile acids is minute, depending only on the presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g. membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues.Usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

Associated Conditions

Radiolucent Cholesterol gallstones

Pharmacodynamics

It acts by reducing levels of cholesterol in the bile, helping gallstones that are made predominantly of cholesterol to dissolve. Chenodeoxycholic acid is ineffective with stones of a high calcium or bile acid content.

Mechanism of action

Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.

Chenodeoxycholic acid is a naturally occurring bile acid that is used to treat patients with genetic deficiencies in the synthesis of bile acids. When given in high doses, cholic acid replacement therapy has been linked to minor elevations in serum aminotransferase levels, but it has not been linked to instances of clinically apparent acute liver injury with jaundice

QINGDAO HAOSAIL COA OF CHENODEOXYCHOLIC ACID 90%
QINGDAO HAOSAIL COA OF CHENODEOXYCHOLIC ACID 95%
QINGDAO HAOSAIL COA OF CHENODEOXYCHOLIC ACID 98%

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