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Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7

China Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7, Find details about China Aakg, 328-50-7 from Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7

Model NO.
L-Arginine Alpha Ketoglutarate
CAS
328-50-7
Appearance
White Solid Powder
Storage
Room Temperature Away From Light
Shelf Life
24month
Deliver Time
7-10 Days
Trademark
Biocar
Transport Package
100g, 1kg, 25kg
Specification
100g, 1kg, 25kg
Origin
Guangzhou China
HS Code
2934999099
Model NO.
L-Arginine Alpha Ketoglutarate
CAS
328-50-7
Appearance
White Solid Powder
Storage
Room Temperature Away From Light
Shelf Life
24month
Deliver Time
7-10 Days
Trademark
Biocar
Transport Package
100g, 1kg, 25kg
Specification
100g, 1kg, 25kg
Origin
Guangzhou China
HS Code
2934999099
Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7
Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7
Detailed Product Information
 
Product Namealpha-ketoglutaric acid
Synonyms2-KETOGLUTARIC ACID;2-OXOGLUTARIC ACID; 2-OXOPENTANEDIOIC ACID;A-KETOGLUTARIC ACID; ALPHA-KETOGLUTARIC ACID;GAMMA-KETOGLUTARIC ACID;FEMA 3891;KETO-GLU
CAS328-50-7
EINECS206-330-3
Molecular formulaC5H6O5
Molecular Weight146.1
Molecular Structure 
Physical and Chemical Properties
M.P. 113-115 °C
B.P.320.7°C at 760 mmHg
Density1.54g/cm3
F.P.147.7°C
Refractive index1.544
FEMA 3891
Storage Temperature2-8°C
 
General DescriptionWhite crystalline powder
Usageα-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.
Packing1kg/bag or 25kg/drum
Specifications 
ItemsStandard
AppearanceWhite crystalline powder
Assay99.0%-101.0%
SolubilityClear
Transmittance≥98%
Loss on drying(%)≤0.5%
Residue on ignition(%)≤0.1
SO42-(%)≤0.02
Cl-(%)≤0.02
NH4+(%)≤0.02
Ca2+(%)≤0.02
Fe3+(ppm)≤10
Heavy metals(as Pb)(pm)≤10
As(ppm)≤1
Total plate count(cfu/g)≤1000
Yeast(cfu/g)≤50
Mold(cfu/g)≤50
E.coli(cfu/g)Negative
Salmonella(cfu/g)Negative
Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7

Describtion:

What Is AKG?
Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogan peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells. In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans.

Food Grade Oral Antioxidative 2-Ketoglutaric Acid Akg Powder USA Stock CAS: 328-50-7


Application of AKG

AKG has been widely used in animals and humans as a feed additive and medicine.
In animal industry, AKG could effectively improve growth performance, nitrogen utilization, immunity, bone development, intestinal mucosal injury, and oxidative system.
In humans, AKG is extensively used in trauma, aged diseases, postoperative recovery, and other nutritional diseases .
 In terms of antioxidative function, AKG exhibits a crucial role in multiple diseases involved in aging, cancer, cardiovascular diseases, and neurological diseases. It has been reported that AKG developed its antioxidant capacity to fight against ethanol toxicity and enhance cold tolerance in the model of Drosophila, which provided an effective therapy against ethanol and alcohol poisoning in animals and humans. Similar protective effect is noticed in lipopolysaccharide-induced liver injury in which AKG provides a new intervention to alleviate liver damage in young pigs . 
AKG also maintains redox state stabilization for antioxidant defense. Indeed, AKG oxidation plays a beneficial role in maintaining the levels of reductive carboxylation to handle mitochondrial defects in cancer cells . Besides, oral administration of AKG improves blood vessel elasticity by exerting its antioxidant in aging organisms .
Additionally, AKG could facilitate the rate of GSH synthesis in human erythrocytes . AKG has been identified to effectively decrease the incidence of cataracts induced by sodium selanite in rat and acted as a scavenger of ROS . Moreover, AKG functions as a neuroprotective agent in ischemic pathology of hippocampus. Furthermore, a novel study demonstrates that AKG could regulate organismal lifespan and prevent age-related diseases by regulating cellular energy metabolism. Interestingly, apart from antioxidative function, AKG is characterized by prooxidative property which can generate active complexes with iron in rat brain homogenates . Under mild oxidative stress, it results in activating antioxidant system of AKG, thus displaying its protective effects such as strengthening resistance of the yeast cells to oxidative stress.

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Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7Healthcare Supplements 99% L-Arginine Alpha Ketoglutarate Increase Collagen Production 328-50-7

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