China API Medicine Lincomycin HCl 99% Lincomycin Hydrochloride Powder CAS No. 859-18-7, Find details about China Lincomycin Hydrochloride, Lincomycin HCl from API Medicine Lincomycin HCl 99% Lincomycin Hydrochloride Powder CAS No. 859-18-7
Introduction
Common Name | Lincomycin hydrochloride |
CAS Number | 859-18-7 |
White | White crystal powder |
Molecular Formula | C18H35ClN2O6S |
Molecular Weight | 442.998 |
Boiling Point | 646.8ºC at 760 mmHg |
Melting Point | 156-158ºC |
FUNCTION
It is mainly used for the treatment of infections caused by Gram-positive bacteria in particular the various penicillin-resistant Gram-positive bacteria , the poultry chronic respiratory disease caused by Mycoplasma, swine enzootic pneumonia, anaerobic infections such as chicken necrotizing enterocolitis.
It can also be used for the treatment of treponema dysentery, toxoplasmosis and actinomycosis of dogs and cats.
APPLICATION
Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis. A related compound, clindamycin, is derived from lincomycin by using thionyl chlorid to replace the 7-hydroxy group with a chlorin atom with inversion of chirality.
Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including actinomycetes, mycoplasma, and some species of Plasmodium. Intramuscular administration of a single dose of 600 mg of Lincomycin produces average peak serum levels of 11.6 micrograms/ml at 60 minutes, and maintains therapeutic levels for 17 to 20 hours, for most susceptible gram-positive organisms. Urinary excretion after this dose ranges from 1.8 to 24.8 percent (mean: 17.3 percent).