GMP Certification Lincomycin HCl/Lincomycin Powder Antibiotic Injection Manufacturing CAS: 859 -18-7

China GMP Certification Lincomycin HCl/Lincomycin Powder Antibiotic Injection Manufacturing CAS: 859-18-7, Find details about China Lincomycin, Pharmaceutical from GMP Certification Lincomycin HCl/Lincomycin Powder Antibiotic Injection Manufacturing CAS: 859-18-7

Basic Info.

Model NO.

Pharmacopoeial grade

CAS

154-21-2

Molecular Formula

C18h34n2o6s

Molecular Weight

406.54

Trademark

Biocar

Transport Package

Aluminum Foil Bags or Fiber Drum

Specification

SGS

Origin

Hubei, China

HS Code

000000000

Model NO.

Pharmacopoeial grade

CAS

154-21-2

Molecular Formula

C18h34n2o6s

Molecular Weight

406.54

Trademark

Biocar

Transport Package

Aluminum Foil Bags or Fiber Drum

Specification

SGS

Origin

Hubei, China

HS Code

000000000

Product Desciption

INFO

Lincomycin HCl
Synonyms: Lincomycin Hydrochloride
CAS: 859-18-7
EINECS 212-726-7
Assay: 82.5~95.5%
Standard: EP7.0/BP/USP
Packing: 20Bou/cardboard drum
MF: C18H35ClN2O6S
MW: 443
Character: White crystalline powder. MP 156-158° C, pH3.5~5.5, Optical rotation +135~+150° . Solubility: H2O: 50 mg/mL, clear, colorless.
Usage: An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
Lincomycin (hereinafter referred to as LCM) biosynthesis, in addition to produce LCM, but under certain conditions, also produced the LCM B, C, D, K, S and other analogues, thus refining process more difficult and costly.
LD50 acute toxicity test showed that mice injected 1000mg/kg, rat oral greater than 4000mg/kg, toxicity is low.
Indications: Effect as erythromycin, do not have to do skin test, the product of Gram-positive bacteria and gram-negative bacteria is stronger for osteomyelitis, sepsis, respiratory and soft tissue infections. This product is very strong penetration of bone, is the medicine of choice for osteomyelitis.

Applications:

Lincomycin is a lincosamide antibiotic that comes from the actinomyces Streptomyces lincolnensis.A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7-hydroxy group with a chlorine atom with inversion of chirality.

Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including actinomycetes, mycoplasma, and some species of Plasmodium.Intramuscular administration of a single dose of 600 mg of Lincomycin produces average peak serum levels of 11.6 micrograms/ml at 60 minutes, and maintains therapeutic levels for 17 to 20 hours, for most susceptible gram-positive organisms. Urinary excretion after this dose ranges from 1.8 to 24.8 percent (mean: 17.3 percent).

A two-hour intravenous infusion of 600 mg of Lincomycin achieves average peak serum levels of 15.9 micrograms/ml and yields therapeutic levels for 14 hours for most susceptible gram-positive organisms. Urinary excretion ranges from 4.9 to 30.3 percent (mean: 13.8 percent).

The biological half-life after IM or IV administration is 5.4 ± 1.0 hours. The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function, compared to patients with normal renal function. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function. Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the serum.

Tissue level studies indicate that bile is an important route of excretion. Significant levels have been demonstrated in the majority of body tissues. Although lincomycin appears to diffuse in the cerebrospinal fluid (CSF), levels of lincomycin in the CSF appear inadequate for the treatment of meningitis.

About US

Biocar Pharma is founded in July 2014 by a group overseas PhD and experienced commercial professionals in Hubei,China. Biocar committed to emerge as a leading of manufacturing, marketing and CMO service of Active Pharmaceutical Ingredients,Intermediates and Herb Extract for global life Science Companies.we have established close and stable cooperative relationship with over 420 manufacturers with long-term with consistent suppliers at India and China.Our mission is to bring products to markets in the most effective & efficient way in terms of high value and quality.Our exports reach more than 105 countries through branches, subsidiaries and distribution network spread across the South Asia, North America ,South America and MEA.Our focus is to add value to the global pharmaceutical industry by serving as a reliable partner.

Our advantages
1.High quality and competitive price is offered
1) For exported we can offer COA Certificate or DMF.
2) We are manufacturer with own lab and factory, can provide high quality products with factory price.
3) Products purity is test by our QC department before sending, and you can also ask the third testing organization come and inspect, such as (SGS/ CTI/ ITS), only after your confirmation will we send it out to you.

2.Fast and safe delivery
1) Products can be sent out in 24 hours after payment. Tracking number available, fixed service person are 7x24h for you to contact.
2) Secure and discreet shipment. Various transportation methods for your choice, like DHL/UPS/TNT/FedEx/SF-express.
3) Customs pass and satisfied rate >99%.
4) For hot sale products we have stock in there for transferring.

3 We have clients throughout the world
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

GMP Certification Lincomycin HCl/Lincomycin Powder Antibiotic Injection Manufacturing CAS: 859-18-7