China Hot Sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib Ditosylate, Find details about China CAS 388082-78-8, Lapatinib Ditosylate from Hot Sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib Ditosylate
Introduction
Product Name: | Lapatinib ditosylate |
Appearance: | Yellow powder |
Assay: | 99%min, 98.0% --101.0% |
Test: | HPLC |
Certificate: | ISO 9001 |
CAS: | 388082-78-8 |
MF: | C29H26ClFN4O4S.2(C7H8O3S) |
Storage Temperature: | Cool Dry Place |
Appearance & Physical State: | colourless to light-yellow crystal |
Density: | 1.403 g/mL (20.84 °C) |
Melting Point: | 237 - 239 °C |
Boiling Point: | 750.7ºC at 760 mmHg |
Flash Point: | 407.8ºC |
Refractive Index: | n20/D 1.5520(lit.) |
Function
Lapatinib produced by glaxosmithkline. Epidermal growth factor receptor tyrosine kinase inhibitor, an oral administration of small molecules. Mainly used for joint card of capecitabine in the treatment of erbB-2 overexpression, who previously received including anthracyclines and paclitaxel and trastuzumab (Herceptin) in the treatment of advanced or metastatic breast cancer. When taking the need to pay attention to its adverse reactions.
In the experiment of Chinese hamster, no carcinogenic effect was found, and no genetic toxicity was found. There was no effect on mating ability and fertility of rats under high dose. There are 1 cases reported in pregnant women in March before taking lapatinib, full-term pregnancy after the birth of healthy children .
Lapatinib in Indonesia and capecitabine combination in the treatment of breast cancer, the effect is better, and of anthracene ring antibiotics, taxanes and trastuzumab resistant patients effective, mild side effects, for advanced or metastatic breast cancer patients and a drug treatment.
Specification
Items | Standards | Results | |
Appearance | White or off-white solid powder | Complies | |
Identification | By IR | Complies | |
By HPLC | Complies | ||
Solubility | Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water | Complies | |
Polymorphic Form | Polymorphic form 1 | Complies | |
Melting Point | 211ºC~216ºC | 212.8ºC~214.9ºC | |
Water Content | ≤ 0.50% | 0.10% | |
Heavy Metals | ≤ 20ppm | Complies | |
Residue on Ignition | ≤ 0.20% | 0.09% | |
Related Substance | Any single impurity: ≤0.10% | 0.06% | |
Total Impurities: ≤1.00% | 0.16% | ||
Assay (on the anhydrous basis) | 98.0%~102.0% | 99.94% | |
Particle Size | D90: ≤100µm | Complies | |
Reference Standard | In-house Standard | ||
Conclusion | The product complied to In-house standard. | ||
Storage | Preserve in tight,light-resistant containers in a cool place |