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China Hot Sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib Ditosylate, Find details about China CAS 388082-78-8, Lapatinib Ditosylate from Hot Sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib Ditosylate

Model NO.
Lapatinib Ditosylate
Mf
C41h40clfn4o11s3
MW
925.46
CAS
388082-78-8
Appearance
Yellow Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag; 25KG/BAG
Origin
China
Model NO.
Lapatinib Ditosylate
Mf
C41h40clfn4o11s3
MW
925.46
CAS
388082-78-8
Appearance
Yellow Powder
Function
Biological and Pharmaceutical Intermediates
Shelf Life
2 Years
Test Method
HPLC UV
Storage
Cool Dry Place
Payment
Tt.Western Union .Credit Card.Moneygram
Delivery Time
Within 2 Days
Certificate
COA MSDS
Sample
Available
Trademark
Faithful
Transport Package
Aluminum Foil Bag Packaging
Specification
10g/bag; 100g/bag; 1kg/bag; 25KG/BAG
Origin
China
Hot Sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib DitosylateHot sales Prulifloxacin CAS 123447-62-1//Levothyroxine Sodium CAS 55-03-8//Lomustine CAS 13010-47-4//Rivanol CAS 6402-23-9//CAS 388082-78-8 Lapatinib Ditosylate

Introduction

Product Name:
Lapatinib ditosylate
  Appearance:Yellow powder
  Assay:99%min, 98.0% --101.0%
  Test:HPLC
  Certificate:ISO 9001
  CAS:388082-78-8
  MF:C29H26ClFN4O4S.2(C7H8O3S)
  Storage Temperature:Cool Dry Place
  Appearance & Physical State:colourless to light-yellow crystal
  Density:1.403 g/mL (20.84 °C)
  Melting Point:237 - 239 °C
  Boiling Point:750.7ºC at 760 mmHg
  Flash Point:407.8ºC
  Refractive Index:n20/D 1.5520(lit.)

Function

Lapatinib produced by glaxosmithkline. Epidermal growth factor receptor tyrosine kinase inhibitor, an oral administration of small molecules. Mainly used for joint card of capecitabine in the treatment of erbB-2 overexpression, who previously received including anthracyclines and paclitaxel and trastuzumab (Herceptin) in the treatment of advanced or metastatic breast cancer. When taking the need to pay attention to its adverse reactions.

 

 In the experiment of Chinese hamster, no carcinogenic effect was found, and no genetic toxicity was found. There was no effect on mating ability and fertility of rats under high dose. There are 1 cases reported in pregnant women in March before taking lapatinib, full-term pregnancy after the birth of healthy children .
 Lapatinib in Indonesia and capecitabine combination in the treatment of breast cancer, the effect is better, and of anthracene ring antibiotics, taxanes and trastuzumab resistant patients effective, mild side effects, for advanced or metastatic breast cancer patients and a drug treatment.

Specification
 

ItemsStandardsResults
AppearanceWhite or off-white solid powderComplies
IdentificationBy IRComplies
By HPLCComplies
SolubilitySoluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in waterComplies
Polymorphic FormPolymorphic form 1Complies
Melting Point211ºC~216ºC212.8ºC~214.9ºC
Water Content≤ 0.50%0.10%
Heavy Metals≤ 20ppmComplies
Residue on Ignition≤ 0.20%0.09%
Related SubstanceAny single impurity: ≤0.10%0.06%
Total Impurities: ≤1.00%0.16%
Assay                  (on the anhydrous basis)98.0%~102.0%99.94%
Particle SizeD90: ≤100µmComplies
Reference StandardIn-house Standard
ConclusionThe product complied to In-house standard.
StoragePreserve in tight,light-resistant containers in a cool place

 

 

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