Professional Exporter Gw0742 CAS 317318-84-6 with Bulk Price
China Professional Exporter Gw0742 CAS 317318-84-6 with Bulk Price, Find details about China Gw0742, CAS 317318-84-6 from Professional Exporter Gw0742 CAS 317318-84-6 with Bulk Price
Basic Info.
Model NO.
Pharmacopoeial grade
CAS
317318-84-6
Name
Gw0742
Einecs Number
1532714-185-1
Shelf Life
2 Years
Storage
2-8 Degrees Celsius
Delivery Time
7-10 Days
Trademark
BIOCAR
Transport Package
Foil Bag and Drum
Specification
kg
Origin
Wuhan, Hubei, China
Model NO.
Pharmacopoeial grade
CAS
317318-84-6
Name
Gw0742
Einecs Number
1532714-185-1
Shelf Life
2 Years
Storage
2-8 Degrees Celsius
Delivery Time
7-10 Days
Trademark
BIOCAR
Transport Package
Foil Bag and Drum
Specification
kg
Origin
Wuhan, Hubei, China
Product Desciption
Professional Exporter GW0742 CAS 317318-84-6 with Bulk Price
Introduction
GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ respectively[1]. GW0742 (100 μM) activates human PPARα and mouse PPARβ in MCF-7 cells. GW0742 (100 μM) significantly reduces low-KCl-induced apoptosis of cerebellar granule neurons. GW0742 shows no obvious inherent toxicity on cerebellar granule neuronal cells after treatment of 3-100 μM for 24 h, but induces increased cell death at 100 μM after 48 hr of treatment. Moreover, GW0742 (100 μM) increases c-Jun expression in cerebellar granule neuron cultures observed at 6 hr[2]. GW0742 (1 μM) induces PPARδ protein in neonatal rat cardiomyocytes. GW0742 also raises mRNA levels of long-chain acyl-CoA dehydrogenase (LCAD), very long-chain acyl-CoA dehydrogenase (VLCAD), acyl-CoA oxidase 1 (ACOX1), uncoupling protein 3 (UCP3), malonyl-CoA decarboxylase (MCD), and pyruvate dehydrogenase kinase 4 (PDK4) in neonatal rat cardiomyocytes.
Service
1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
------Suitable for under 50kg, Fast:3-7 days.
High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:3-7 days,
High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
Business cooperation of chemical reagent
Nowadays, more and more traders ask us about the wholesale of chemical reagent, as the request the our sales department, we show our guide on here, please check details below:
1.Quality
We only purchase the TOP quality reagent in China market, we seek the long-term, stable cooperation. Our principle: Reject fake goods! Reject low quality! Otherwise the quality problem will bring much trouble, in the whole progress.
2.Price
In the standard of quality, our price is absolutely as same as local China market. For explanation, we do organic synthesis 12 years, almost all the chem reagent companies have the stable relationship with us. We can purchase at 10%-20% discount, so this part is our profit. So we will draft the MOQ($10,000) between us.
3.Sincere and Honesty
We bring out the whole sincere, if you are doubt if our price is really as same as local China market, we will send the example list, you can compare with the price standard. Then please give us the certain answer, only one thing: "We are certain to buy or not?" If yes, send us the quotation list, we fill the information in it.
Common questions:
1.About the Shipping
You'd better provide the forwarder, it is suit for yourself. The best method is you can receive goods in local China, we provide the FOB service. If not, don't worry, we have professional forwarder can do the shipping of variety chemicals.
2.100% T/T in advance
In the whole business, you can be served by us. And we will provide the clear lead time and obey it, so absolutely don't worry our work, and please don't let the financial issue block the schedule of business.
3.Dangerous goods, we negotiate alone.
We also have professional forwarder of dangerous goods, as for it, we can quote independently.
==================================================================================================
Contact:
Telephone: +86-027-87002705
Mobile: +86-15623141720
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.Biocar is a reliable supplier and looks for a long term business relationship!!!
| Product Name | GW0742 | ||
| Cas No. | 317318-84-6 | Delivery time | 7-10 days |
| EINECS No. | 1532714-185-1 | Storage | 2-8 degrees Celsius |
| Appearance | white powder | MW | 471.49 |
| Shelf life | 2 years | MF | C21H17F4NO3S2 |
Introduction
GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ respectively[1]. GW0742 (100 μM) activates human PPARα and mouse PPARβ in MCF-7 cells. GW0742 (100 μM) significantly reduces low-KCl-induced apoptosis of cerebellar granule neurons. GW0742 shows no obvious inherent toxicity on cerebellar granule neuronal cells after treatment of 3-100 μM for 24 h, but induces increased cell death at 100 μM after 48 hr of treatment. Moreover, GW0742 (100 μM) increases c-Jun expression in cerebellar granule neuron cultures observed at 6 hr[2]. GW0742 (1 μM) induces PPARδ protein in neonatal rat cardiomyocytes. GW0742 also raises mRNA levels of long-chain acyl-CoA dehydrogenase (LCAD), very long-chain acyl-CoA dehydrogenase (VLCAD), acyl-CoA oxidase 1 (ACOX1), uncoupling protein 3 (UCP3), malonyl-CoA decarboxylase (MCD), and pyruvate dehydrogenase kinase 4 (PDK4) in neonatal rat cardiomyocytes.
Service
1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Shipping Advise
1. By Express------Suitable for under 50kg, Fast:3-7 days.
High cost; Door to door service. Easy to pick up the goods.
2. By Air
------Suitable for more than 50 kg, Fast:3-7 days,
High cost, airport to airport. professional broker needed.
3. By sea
------Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
Business cooperation of chemical reagent
Nowadays, more and more traders ask us about the wholesale of chemical reagent, as the request the our sales department, we show our guide on here, please check details below:
1.Quality
We only purchase the TOP quality reagent in China market, we seek the long-term, stable cooperation. Our principle: Reject fake goods! Reject low quality! Otherwise the quality problem will bring much trouble, in the whole progress.
2.Price
In the standard of quality, our price is absolutely as same as local China market. For explanation, we do organic synthesis 12 years, almost all the chem reagent companies have the stable relationship with us. We can purchase at 10%-20% discount, so this part is our profit. So we will draft the MOQ($10,000) between us.
3.Sincere and Honesty
We bring out the whole sincere, if you are doubt if our price is really as same as local China market, we will send the example list, you can compare with the price standard. Then please give us the certain answer, only one thing: "We are certain to buy or not?" If yes, send us the quotation list, we fill the information in it.
Common questions:
1.About the Shipping
You'd better provide the forwarder, it is suit for yourself. The best method is you can receive goods in local China, we provide the FOB service. If not, don't worry, we have professional forwarder can do the shipping of variety chemicals.
2.100% T/T in advance
In the whole business, you can be served by us. And we will provide the clear lead time and obey it, so absolutely don't worry our work, and please don't let the financial issue block the schedule of business.
3.Dangerous goods, we negotiate alone.
We also have professional forwarder of dangerous goods, as for it, we can quote independently.
| Our Advantages / The 7 reasons are as below: | ||
| 1 | Rich experience | Our company is a professional leading supplier in pharmaceutical and chemical area for many years. |
| 2 | Suitable packagings | The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken in consideration |
| 3 | High quality | High quality guaranteed, product is tested before shipment. |
| 4 | Secure shipping | Shipping by professional forwarder Security EMS/DHL/TNT/FedEx/UPS,AusPost, Royal Mail express,etc.Door to door service. |
| 5 | Fast delivery | We have stock, so we can deliver quickly once payment isreceived. |
| 6 | Quality service | Warm aftersale service is supplied,if any question we will reply you within 8 hours. |
| 7 | Competitive prices | A discount would be given when you make a large order. VIP price for next orders. |
==================================================================================================
Contact:
Telephone: +86-027-87002705
Mobile: +86-15623141720
Online Store: http://biocar.en.made-in-china.com/
©Wuhan Newbio Pharm-Tech Co., Ltd.Biocar is a reliable supplier and looks for a long term business relationship!!!
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