Haosail Provide High Purity 98% Cholic Acid

China Haosail Provide High Purity 98% Cholic Acid, Find details about China Cholan-24-Oic Acid, Molecular Formula: C24h40o5 from Haosail Provide High Purity 98% Cholic Acid

Model NO.
HSCA001
Name
Cholic Acid
Synonyms
Dl-Alpha-Lipoic Acid
Synonyms-2
Cholan-24-Oic Acid
Synonyms-3
3alpha, 7alpha, 12alpha-Trihydroxy-5beta-Cholanic AC
Molecular Formula
C24h40o5
Molecular Weight
408.58
CAS Registry Number
81-25-4
Melting Point
197-202 ºC
Water Solubility
0.28 G/L (15 ºC)
Trademark
HAOSAIL
Transport Package
25kgs/Drum
Specification
50%; 80%; 90%; 95%; 99%
Origin
Qingdao China
HS Code
2942000000
Model NO.
HSCA001
Name
Cholic Acid
Synonyms
Dl-Alpha-Lipoic Acid
Synonyms-2
Cholan-24-Oic Acid
Synonyms-3
3alpha, 7alpha, 12alpha-Trihydroxy-5beta-Cholanic AC
Molecular Formula
C24h40o5
Molecular Weight
408.58
CAS Registry Number
81-25-4
Melting Point
197-202 ºC
Water Solubility
0.28 G/L (15 ºC)
Trademark
HAOSAIL
Transport Package
25kgs/Drum
Specification
50%; 80%; 90%; 95%; 99%
Origin
Qingdao China
HS Code
2942000000

We are the most professional real "MANUFACTURER" and "SUPPLIER" of CHOLIC ACID series materials on MIC, welcome the enquiry from both Foreign and Domestic customers.

 

We can provide:

(1) Cholic Acid (Free Grade 50%)                                                             CAS #:81-25-94

(2) Cholic Acid (Food Grade 90%)                                                            CAS #:81-25-94

(3) Cholic Acid (Pharmaceutical Grade 95%;98%)                                CAS #:81-25-94

(4) Chenodeoxycholic Acid(intermediate of Ursodeoxycholic Acid)      CAS #:474-25-9

(5) 3alpha-Hydroxy-7-oxo-5beta-cholic acid(7K-LCA)                           CAS #:4651-67-6

(6) Ursodeoxycholic Acid(EP9/USP/IP GRADE WITH GMP)               CAS #:128-13-2  

(7)Tauroursodeoxycholic acid   EP9                                                           CAS #:14605-22-2
(8)Obeticholic Acid  (OBCA)  98%/99%                                                   CAS #:459789-99-2
(9)Obeticholic Acid Intermediate-1(OB N-1)                                            CAS #:915038-26-5
(10)Obeticholic Acid Intermediate-2(OB N-2)                                          CAS #:1516887-33-4
(11)Obeticholic Acid Intermediate-3(OB M-2)                                          CAS#:1352328-66-5

 

Description:

Product Name:Cholic Acid

CAS:81-25-94
Molecular Formula: C24H4005
Molecular Mass:408.58
[Appearance]: white crystal powder, no foreign substance, no obvious odor
[Melting Point]: 197~202.0ºC
[Loss on Dry]: ≤1.0%
[Residue on Ignition]: ≤0.1%
[Heavy Metal ]: ≤10ppm
[Assay Determination]: 98.0%~101.0% (dries basis)
[Related Substance]:the single impurity≤0.1%, total impurities≤2.0%
[Package and Storage Condition]: 25kg/drum, store and seal away from light

 

What is cholic acid?
Cholic acid is a bile acid. Bile acids are produced naturally in the body to aid in digestion of fats and certain nutrients.
People with bile acid disorders are unable to produce cholic acid normally. This can make it harder for the body to absorb nutrients important for health, growth, and body functioning. Abnormal bile acids can also build up in the body and become toxic to the liver.
Cholic acid is used in people with bile acid disorders. This medicine works by normalizing bile acid production in the body.
Cholic acid may also be used for purposes not listed in this medication guide.



 

Bile acid is an important component of bile and plays an important role in fat metabolism. Bile acidsare mainly found in the enterohepatic circulatory system and play a protective role through recycling. Only a small portion of bile acids enters the peripheral circulation.


The driving force for promoting bile acid enterohepatic circulation is the liver cell transport system --- absorb bile acid and secrete it into bile, cholecystokinin-induced gallbladder contraction, small bowel advancing peristalsis, active transport of ileum mucosa, and Inflow.
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol. These two major bile acids are roughly equal in concentration in humans.Derivatives are made from cholyl-CoA, which exchanges its CoA with either glycine, or taurine, yielding glycocholic and taurocholic acid, respectively.
Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).
Cholic acid and chenodeoxycholic acid are the most important human bile acids. Other species may synthesize different bile acids as their predominant primary bile acids.

Cholic acid, sold under the brand name Cholbam, is approved for use in the United States and is indicated as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome).
It was approved for use in the European Union in September 2013, and is sold under the brand name Orphacol. It is indicated for the treatment of inborn errors in primary bile-acid synthesis due to 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency or Δ4-3-oxosteroid-5β-reductase deficiency in infants, children and adolescents aged one month to 18 years and adults.
Cholic acid FGK (Kolbam) was approved for medical use in the European Union in November 2015. It is indicated for the treatment of inborn errors of primary bile acid synthesis, in infants from one month of age for continuous lifelong treatment through adulthood, encompassing the following single enzyme defects:
1>sterol 27-hydroxylase (presenting as cerebrotendinous xanthomatosis, CTX) deficiency;
2>2- (or alpha-) methylacyl-CoA racemase (AMACR) deficiency;
3>cholesterol 7 alpha-hydroxylase (CYP7A1) deficiency.
The most common side effects include peripheral neuropathy (nerve damage in the hands and feet), diarrhea, nausea (feeling sick), acid reflux (stomach acid flowing up into the mouth), esophagitis (inflammation of the food pipe), jaundice (yellowing of the skin and eyes), skin problems (lesions) and malaise (feeling unwell).

Cholic acid is a naturally occurring bile acid that is used to treat patients with genetic deficiencies in the synthesis of bile acids. When given in high doses, cholic acid replacement therapy has been linked to minor elevations in serum aminotransferase levels, but it has not been linked to instances of clinically apparent acute liver injury with jaundice


 

Product NameCholic Acid
Assay50%;90%;95%;98%
AppearanceWhite Powder
Shelf life2 years
BrandHAOSAIL

 

 


QINGDAO HAOSAIL COA OF CHOLIC ACID
Haosail Provide High Purity 98% Cholic Acid

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Haosail Provide High Purity 98% Cholic Acid

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Qingdao Haosail Science Co., Ltd is a joint stock company, stock No. is 839542. We are manufacturer and globalsupplier of Spirulina,Chlorella, Spirulina blue(phycocyanin) and nutritional ingredients, and also a flexible and leading contract manufacturer of nutritional and dietary supplements, our products include powders, diversified tablets, hardgel capsules and softgel capsules, in bulk packaging and all kinds of retail packaging.

Also, based on our professional experience and capability of sourcing and purchasing diverse nutritional ingredients in China, we also provide our customers with a full range of raw materials which are used in Nutritional and Dietary industry. Our people are proficient in the knowledge and specialty of nutritional ingredients, so we are confident that we are able to offer the right and best ingredients to you. Moreover, benefit from our strategic partnership with many key manufacturers of nutritional ingredients, as well as our collective purchasing, we are able to offer very competitive price to you.

Our people is dedicated to supply nutritional and dietary products according to customers' requirements with consistently high quality and considerate service.

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Haosail Provide High Purity 98% Cholic Acid