Top Grade Purity Cisplatin Powder Cisplatin 99% CAS 15663-27-1

Product name:Cisplatin
CAS NO:15663-27-1
Molecular Formula:C15H17NO2
Appearance:White powder
Purity:99%
Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.
This product is a heavy metal complex center at two price of platinum with two ammoniamolecule, similar to the bifunctional alkylating agent, can inhibit the DNA replication process. The most sne DDP cells, high concentrations inhibit RNA and protein synthesis. The lack of effect of oxygen cells, into the human body can diffuse through the cell membrane charged. At present, the main site of DDP in DNA of the purine and pyrimidine bases. Effect: This product is a cell cycle non-specific drugs, has the cell toxicity, the process of DNA replication can inhibit cancer cells, and damage to the cell membrane structure, a broad-spectrum anticancer role.

Function

Cisplatin used to treat testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.
Application
Cisplatin used to treat testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical, stomach and prostate cancers. Also to treat Hodgkin's and non-Hodgkin's lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma.
Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II)  is a platinum-based chemotherapydrug used to treat various types of cancers, including sarcomas, somecarcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, andgerm cell tumors.
It was the first member of a class of anti-cancer drugs which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA which ultimately triggers apoptosis (programmed cell death).