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Product name :Spectinomycin Hydrochloride

Formula: C14H26Cl2N2O7

Molecular Weight: 405.27

CAS No.: 21736-83-4

Purity: 99%

Melting Point:194°C

 1. To narrow spectrum antibiotics effective only gram-positive bacteria, such as hemolytic streptococcus, pneumococcus, Neisseria gonorrhoeae and other enterococci are sensitive to resistant Staphylococcus aureus is especially sensitive to this product. The mechanism is to inhibit the synthesis of bacterial cell wall, which combines primary and bacterial cell wall, leaving certain amino acids can not enter in the cell wall glycopeptides. Penicillin-resistant S. aureus is mainly used for clinical caused by serious infections such as pneumonia, endocarditis.

 2. Vancomycin is indicated for the treatment of serious, life-threatening infections by gram-positive bacteria unresponsive to other antibiotics. In particular, vancomycin should not be used to treat methicillin-sensitive Staphylococcus aureus because it is inferior to penicillins such as nafcillin.

3. Treatment of serious infections caused by susceptible organisms resistant to penicillins (Methicillin-resistant Staphylococcus aureus(MRSA) and multiresistant Staphylococcus epidermidis (MRSE)) or in individuals with serious allergy to penicillins.

 Spectinomycin dihydrochloride pentahydrate is an aminocylcitol antibiotic which is closely related to the aminoglycosides. Gram-positive and gram-negative Gonococcus spp. are reported to exhibit susceptibility to Spectinomycin. Studies indicate that Spectinomycin interferes with peptidyl tRNA translocation thereby affecting protein synthesis in susceptible bacteria. Additional reports note that mutations in ribosomal proteins may prevent the binding of spectinomycin, thus potentially confering resistence to the compound. Additionally, Eschericia coli is reported to be reversibly inhibited during growth and division by Spectinomycin and that variations in bacterial sensitivity may be mediated by differences in ribosomes among different E. coli mutants.