Hot Sale 2-Deoxy-D- Glucose CAS 154-17-6 with Best Price in Stock
China Hot Sale 2-Deoxy-D-Glucose CAS 154-17-6 with Best Price in Stock, Find details about China 2-Deoxy-D-Glucose, 2 Deoxyglucose from Hot Sale 2-Deoxy-D-Glucose CAS 154-17-6 with Best Price in Stock
| Product Name: | 2-Deoxy-D-glucose |
| Synonyms: | 2-Deoxy-D-glucose, Min. 98%;2-deoxy-d-arabino-hexos;2-deoxy-d-glucos;2-deoxy-d-mannose;2-deoxy-glucos;2-desoxy-d-glucose;D-2-GLUCODESOSE;2-DEOXY-D-ARABINOHEXOSE |
| CAS: | 154-17-6 |
| MF: | C6H12O5 |
| MW: | 164.16 |
| EINECS: | 205-823-0 |
| Product Categories: | Pharmaceutical Raw Materials;chiral;Biochemistry;Deoxysugars;Glucose;Sugars;Carbohydrates & Derivatives |
| Mol File: | 154-17-6.mol |
2-Deoxy-D-glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.
2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel). By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in
diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to
chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors).
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