Wholesales Ectoine CAS 96702-03-3 with Low Price
Product Details:Product Name: | Ectoine |
Synonyms: | ECTOIN;(S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID;THP[B];ECTOINE;2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID;(S)-1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsure;ECTOINE BIOCHEMIKA 99%;Ectoine sodium salt monohydrate |
CAS: | 96702-03-3 |
MF: | C6H10N2O2 |
MW: | 142.16 |
EINECS: | 431-910-1 |
Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;CARBOXYLICACID;API;1 |
Mol File: | 96702-03-3.mol |
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Product Physicochemical properties:Like other compatible solutes, ectoine and 5-hydroxyectoine are low-molecular mass compounds that are highly soluble in water (about 4 M at 20ÂșC), thereby allowing the amassing of these compounds to near molar concentrations in severely osmotically stressed microbial cells. A variety of biophysical techniques have been used to study the effects of ectoine on the hydration of proteins and cell membranes and on interactions mediated via hydrogen bonding. Collectively, these data revealed that ectoine is excluded from the monolayer of dense hydration water around soluble proteins and from the immediate hydration layer at the membrane/liquid interface. Ectoine enhances the properties of hydrogen bonds in aqueous solutions and thereby contributes to the dynamics and stabilization of macromolecular structures. Ectoine possesses a negatively charged carboxylate group attached to a ring structure that contains a delocalized positive charge. The resulting interplay between hydrophilic and hydrophobic forces influences waterwater and water-solute interactions and thereby exerts strong effects on the hydration of ectoine itself, the binding of ions and the influence on the local water structure. Molecular dynamics simulations have indicated that ectoine and 5-hydroxyectoine are strong water-binders and are able to accumulate seven and nine water molecules, respectively, around them at a distance smaller than 0.6 nm. Collectively, the physico-chemical attributes of ectoine allow a physiologically adequate hydration of the cytoplasm upon their osmostress-responsive accumulation, afford effects on the local water structure, and also exert a major protective influence on the stability of proteins and the functionality of macromolecules.
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