Product DescriptionSupply CAS 154-17-6 2-Deoxyglucose 2-Deoxy-D-glucose 2-DG Powder Powder |
Name | 2-Deoxy-D-glucose |
Other name | 2-deoxyglucose 2-Deoxy-D-arabino-hexose 2-deoxy-D-glucose 2-DG D-arabino-2-desoxyhexose |
CAS NO. | 154-17-6 |
Molecular Formula | C6H12O5 |
Molecular Weight | 164.1565 |
IntroductionWhat is 2-Deoxy-D-glucose ?
2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel). By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors). Real Shot
Function & Application
2-Deoxy-D-glucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel).
By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck,and gastric tumors). The exact mechanisms of action of 2-deoxyglucose is still being investigated, but it is known that in hypoxic cancer cells, 2-deoxyglucose is a glycolysis inhibitor that prevents ATP production and, ultimately, cell survival. With respect to antiviral therapy, 2-deoxyglucose was shown to be effective against herpes simplex virus by affecting the virus' ability to penetrate cells. As an
experimental drug, 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal lobe epilepsy. In this condition, 2-deoxyglucose represses the expression of certain proteins that are at high levels after a seizure. Although there are several possible therapeutic indications for 2-deoxyglucose presently there is no approved indication for 2-deoxyglucose as a therapeutic agent.
COA
Item | Specifications | Results |
Appearance | A white or almost white crystalline powder | Conform |
Heavy Metal | ≤10ppm | Conform |
Residue on ignition | ≤0.2% | 0.06% |
Sulfide | ≤0.05% | 0.01% |
Loss on drying | ≤2.0% | 0.95% |
Assay | ≥95.0% | 95.8% |
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