Ethambutol Hydrochloride Tablets for The Treatment of Tuberculosis Caused by Tuberculosis Bacilli in Combination with Other Anti-Tuberculosis Drugs
China Ethambutol Hydrochloride Tablets for The Treatment of Tuberculosis Caused by Tuberculosis Bacilli in Combination with Other Anti-Tuberculosis Drugs, Find details about China Ethambutol Hydrochloride Tablets, Ethambutol from Ethambutol Hydrochloride Tablets for The Treatment of Tuberculosis Caused by Tuberculosis Bacilli in Combination with Other Anti-Tuberculosis Drugs
Basic Info.
Model NO.
CF043
Model NO.
CF043
Product Desciption
Product name Ethambutol Hydrochloride Tablets
General name ethambutol hydrochloride tablets
The main ingredient of this product is ethambutol hydrochloride.
Indications This product is suitable for the treatment of tuberculosis caused by tuberculosis bacilli in combination with other anti-tuberculosis drugs. It can also be used for the treatment of tuberculous meningitis and atypical mycobacterium infection.
1. The incidence of blurred vision, eye pain, red and green color blindness or visual impairment, reduced field of vision (optic neuritis is prone to occur when the daily dose of weight is more than 25mg/kg). Visual changes may be unilateral or bilateral.
2. Less incidence of chills, joint swelling and pain (especially big toe, condyle and knee), and skin fever and tension on the surface of the diseased joint (acute gout and hyperuricemia).
3. Rash, fever, joint pain and other allergic reactions are rare; Or numbness, tingling, burning pain, or weakness in the hands and feet (peripheral neuritis).
There are no reliable references that did not perform the experiment.
1. Interferences to diagnosis: the use of this product can increase the measured value of blood uric acid concentration.
2. The following conditions should be used with caution: gout, optic neuritis, and renal dysfunction.
3. Check up during treatment. Eye, visual field, visual acuity, red and green discrimination, etc., should be checked once a day before and during the course of medication, especially for patients with a long course of medication and a daily dose of more than 15mg/kg. Serum uric acid determination, because this product can make serum uric acid concentration increase, cause gout attack. Therefore, it should be measured regularly in the course of treatment.
If gastrointestinal irritation occurs, ethambutol can be taken with food. The daily dose divided into several doses may not reach the effective blood concentration, so the daily dose of this product should be taken at one time.
5. Ethambutol can rapidly develop resistance when used alone and must be used in combination with other anti-TB drugs. This product should be used in combination with at least one drug in patients who have received antituberculous drugs.
6. Since there is no practical method to determine the blood drug concentration, the dose should be calculated according to the patient's body weight. In patients with reduced liver or renal function, the plasma concentration of this product may increase and the half-life may be prolonged. The dose should be reduced in patients with renal dysfunction.
Ethambutol can pass through the placenta, and the fetal blood concentration is about 30% of the maternal blood concentration. High dose of this product in mice can cause cleft palate, brain exposure and spinal deformity; High dose of this product can induce mild cervical deformity in rats. In domestic rabbits, high dose of this product can cause Cyclops, short limbs, cleft lip and palate and other deformities. Although it has not been proven in humans, its use in pregnant women must be fully weighed against the risks. The effects of this product on the fetus when used in combination with other drugs are unknown.
2. Ethambutol can be distributed in milk at a concentration similar to that of blood drugs, although it has not been proven to be a problem in humans, and the use of ethambutol in lactating women must be weighed against the pros and cons.
Clinical data for children under 13 years of age are scarce. This product is not recommended for children under 13 years of age because it is difficult to monitor visual changes in young children.
The elderly often accompanied by physiological renal function decline, so the dosage should be adjusted according to renal function.
Drug Interactions 1. Adverse reactions may be increased when used in combination with ethionotinamide.
2. Use with aluminum hydroxide to reduce absorption of this product.
3. Combined with neurotoxic agents, such as optic neuritis or peripheral neuritis, may increase the neurotoxicity of this product.
Drug overdose 1. Drug overdose mainly presents the symptoms described in [Adverse Reactions], and permanent optic nerve atrophy may occur in severe cases.
2. Treatment of drug overdose:
(1).
(2) Symptomatic treatment:
Retrobulbar optic neuritis patients can use vitamin B6, complex vitamins and zinc and copper preparations.
(2) To restore eyesight, dexamethasone 5mg can be used, intravenously or after the ball injection every day; Tolasurin 12.5mg, daily after ball injection; Cortisone chloride 200mg, intravenously daily. Prednisone 20mg orally, 2 ~ 3 times a day. At the same time to give vitamins and so on. During the recovery period, acupuncture therapy, oral administration of dipazole, niacin, etc., or daily intramuscular injection of placental tissue fluid can be given.
Hemodialysis and peritoneal dialysis should be performed when necessary.
Drug toxicology Pharmacological action:
This product is a synthetic antimicrobial anti-tuberculosis drug. The mechanism of action has not been fully elucidated. This product can penetrate into the biosynthesis of interfering RNA in the body of polytechnical bacilli, thus inhibiting the reproduction of bacteria, this product is only effective on the growth and reproduction of mycobacterium. So far, no cross-resistance between this product and other anti-tuberculosis drugs has been found.
Toxicological studies:
This experiment was not conducted and no reliable references were available.
Pharmacokinetics After oral administration, 75% ~ 80% was absorbed through the gastrointestinal tract. Widely distributed in the body tissues and body fluids (except cerebrospinal fluid). The drug concentration in erythrocyte was the same as or twice as that in plasma, and could last for 24 hours. Higher concentrations of drugs in kidney, lung, saliva and urine; However, the concentrations in pleural fluid and ascites were lower. This product does not penetrate normal meninges, but there may be trace amounts in cerebrospinal fluid in patients with tuberculous meningitis. Its distribution volume is 1.6L/kg. Protein binding rate is about 20% ~ 30%. Blood concentration can reach its peak within 2 ~ 4 hours after oral administration, and the half-life (t1/2) is 3 ~ 4 hours, which can be extended to 8 hours in patients with renal dysfunction. It is mainly metabolized by the liver, and about 15% of the dose is metabolized to inactive metabolites. Through glomerular filtration and secretion of renal tubules; About 80% are excreted within 24 hours after administration, at least 50% are excreted in their original form, and about 15% are inactive metabolites. In the faeces with the original form of excretion about 20%. The drug concentration in the milk is approximately equivalent to that in the mother's blood. Considerable amounts of ethambutol can be removed from the body by hemodialysis and peritoneal dialysis.
Storage shading, sealed preservation.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
General name ethambutol hydrochloride tablets
The main ingredient of this product is ethambutol hydrochloride.
Indications This product is suitable for the treatment of tuberculosis caused by tuberculosis bacilli in combination with other anti-tuberculosis drugs. It can also be used for the treatment of tuberculous meningitis and atypical mycobacterium infection.
1. The incidence of blurred vision, eye pain, red and green color blindness or visual impairment, reduced field of vision (optic neuritis is prone to occur when the daily dose of weight is more than 25mg/kg). Visual changes may be unilateral or bilateral.
2. Less incidence of chills, joint swelling and pain (especially big toe, condyle and knee), and skin fever and tension on the surface of the diseased joint (acute gout and hyperuricemia).
3. Rash, fever, joint pain and other allergic reactions are rare; Or numbness, tingling, burning pain, or weakness in the hands and feet (peripheral neuritis).
There are no reliable references that did not perform the experiment.
1. Interferences to diagnosis: the use of this product can increase the measured value of blood uric acid concentration.
2. The following conditions should be used with caution: gout, optic neuritis, and renal dysfunction.
3. Check up during treatment. Eye, visual field, visual acuity, red and green discrimination, etc., should be checked once a day before and during the course of medication, especially for patients with a long course of medication and a daily dose of more than 15mg/kg. Serum uric acid determination, because this product can make serum uric acid concentration increase, cause gout attack. Therefore, it should be measured regularly in the course of treatment.
If gastrointestinal irritation occurs, ethambutol can be taken with food. The daily dose divided into several doses may not reach the effective blood concentration, so the daily dose of this product should be taken at one time.
5. Ethambutol can rapidly develop resistance when used alone and must be used in combination with other anti-TB drugs. This product should be used in combination with at least one drug in patients who have received antituberculous drugs.
6. Since there is no practical method to determine the blood drug concentration, the dose should be calculated according to the patient's body weight. In patients with reduced liver or renal function, the plasma concentration of this product may increase and the half-life may be prolonged. The dose should be reduced in patients with renal dysfunction.
Ethambutol can pass through the placenta, and the fetal blood concentration is about 30% of the maternal blood concentration. High dose of this product in mice can cause cleft palate, brain exposure and spinal deformity; High dose of this product can induce mild cervical deformity in rats. In domestic rabbits, high dose of this product can cause Cyclops, short limbs, cleft lip and palate and other deformities. Although it has not been proven in humans, its use in pregnant women must be fully weighed against the risks. The effects of this product on the fetus when used in combination with other drugs are unknown.
2. Ethambutol can be distributed in milk at a concentration similar to that of blood drugs, although it has not been proven to be a problem in humans, and the use of ethambutol in lactating women must be weighed against the pros and cons.
Clinical data for children under 13 years of age are scarce. This product is not recommended for children under 13 years of age because it is difficult to monitor visual changes in young children.
The elderly often accompanied by physiological renal function decline, so the dosage should be adjusted according to renal function.
Drug Interactions 1. Adverse reactions may be increased when used in combination with ethionotinamide.
2. Use with aluminum hydroxide to reduce absorption of this product.
3. Combined with neurotoxic agents, such as optic neuritis or peripheral neuritis, may increase the neurotoxicity of this product.
Drug overdose 1. Drug overdose mainly presents the symptoms described in [Adverse Reactions], and permanent optic nerve atrophy may occur in severe cases.
2. Treatment of drug overdose:
(1).
(2) Symptomatic treatment:
Retrobulbar optic neuritis patients can use vitamin B6, complex vitamins and zinc and copper preparations.
(2) To restore eyesight, dexamethasone 5mg can be used, intravenously or after the ball injection every day; Tolasurin 12.5mg, daily after ball injection; Cortisone chloride 200mg, intravenously daily. Prednisone 20mg orally, 2 ~ 3 times a day. At the same time to give vitamins and so on. During the recovery period, acupuncture therapy, oral administration of dipazole, niacin, etc., or daily intramuscular injection of placental tissue fluid can be given.
Hemodialysis and peritoneal dialysis should be performed when necessary.
Drug toxicology Pharmacological action:
This product is a synthetic antimicrobial anti-tuberculosis drug. The mechanism of action has not been fully elucidated. This product can penetrate into the biosynthesis of interfering RNA in the body of polytechnical bacilli, thus inhibiting the reproduction of bacteria, this product is only effective on the growth and reproduction of mycobacterium. So far, no cross-resistance between this product and other anti-tuberculosis drugs has been found.
Toxicological studies:
This experiment was not conducted and no reliable references were available.
Pharmacokinetics After oral administration, 75% ~ 80% was absorbed through the gastrointestinal tract. Widely distributed in the body tissues and body fluids (except cerebrospinal fluid). The drug concentration in erythrocyte was the same as or twice as that in plasma, and could last for 24 hours. Higher concentrations of drugs in kidney, lung, saliva and urine; However, the concentrations in pleural fluid and ascites were lower. This product does not penetrate normal meninges, but there may be trace amounts in cerebrospinal fluid in patients with tuberculous meningitis. Its distribution volume is 1.6L/kg. Protein binding rate is about 20% ~ 30%. Blood concentration can reach its peak within 2 ~ 4 hours after oral administration, and the half-life (t1/2) is 3 ~ 4 hours, which can be extended to 8 hours in patients with renal dysfunction. It is mainly metabolized by the liver, and about 15% of the dose is metabolized to inactive metabolites. Through glomerular filtration and secretion of renal tubules; About 80% are excreted within 24 hours after administration, at least 50% are excreted in their original form, and about 15% are inactive metabolites. In the faeces with the original form of excretion about 20%. The drug concentration in the milk is approximately equivalent to that in the mother's blood. Considerable amounts of ethambutol can be removed from the body by hemodialysis and peritoneal dialysis.
Storage shading, sealed preservation.
FAQ
1.who are we?
We are based in Fujian, China, start from 2000,sell to North America(40.00%),Southeast Asia(25.00%),Western Europe(25.00%),Africa(10.00%).There are total about 50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Pharmaceutical production lines,Intermediates,APIs,Finished Drug Preparations & Vaccines.
4. why should you buy from us not from other suppliers?
We have our own manufacture factories and one professional sales team working for the clients all over the world.
5. what services can we provide?
Accepted Delivery Terms: FOB,CIF,EXW,DDP,Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,GBP,CNY;
Accepted Payment Type: T/T,L/C,PayPal,Western Union;
Language Spoken:English,Chinese,Japanese
Our Ddvantage:
1. Quick delivery
2. Online payment
3. Quality assurance
4. Welcome big order
5. After-sales service 24 hours
6. Competitive advantage products
7. Our value information is "Quality is our culture"
8. Work with us to provide you with secure funds, your business is securely protected, our advantages
Our Service
a) Free amples can be provided.
b) Guide customers through professional technology and teach them how to use our products after sale
c) Determine the lowest price of high-quality products
1. Skilled experience: Our company is a leading manufacturer of professional production in China pharmaceutical field for many years.
2. The highest quality: to ensure high quality, once any problems are found, the package will be re-shipped for you.
3. Safe transportation: by air express (FedEx, UPS, DHL, EMS). It is recommended that you choose the most professional freight forwarder.
4. Fast delivery: We have stock, so once payment is received, we can deliver quickly.
5. Quality service: We will provide you with enthusiastic after-sales service. If you have any questions, we will reply to youwithin 24 hours.
6. Competitive price: discounts will be obtained when making large orders.
Our Manufacture Factory
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded FUL has been put into operation in many well-known pharmaceutical enterprises such as SINOPHARM, CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd business radiates to all levels, including direct supply cooperation with government departments and industry representatives, as well as establishing supply cooperation relationship with retail industry. We supply high quality, safe and effective medicines and medical equipment to governments, hospitals, clinics and licensed pharmacies in different countries with timely and effective services at reasonable prices.
At present Fuzhou FUL Fluid Equipment & Pharmaceutical Co., Ltd has the SINOPHARM authorization to sell its intermediates and APIs,and has the authorizations of CSPC & HUABEI PHARM sell its finished drug preparations;then FUL is the only manufacture in China which can supply the complete service from pharmaceutical produciton lines,intermediates and APIs to finished drug preparations and vaccines.Then we are seeking the professional pharmaceutical enterprices to work together for further cooperations.
Factory View
Our Products
Our Business
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