The hydroxychloroquine sulfate is an antimalarial drug that also has anti-inflammatory, immunomodulatory and anticoagulant effects. At present, hydroxychloroquine is mainly used in clinical treatment of rheumatoid arthritis, juvenile chronic arthritis, discoid lupus erythematosus and systemic erythema. It related to stabilizing the lysosomal membrane, inhibiting the formation of prostaglandins, inhibiting the chemotacticity of polymorphonuclear cells and the role of phagocytic cells, and may interfere with monocyte interleukin- 1 formation and inhibition of neutrophil superoxide release.

The hydroxychloroquine sulfate is a synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties, Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites (Plasmodium vivax, ovale, and malariae) by concentrating in food vacuoles. It inhibits plasmodial heme polymerase and acts through other unknown mechanisms. Hydroxychloroquine also has anti-inflammatory properties and used in the treatment of rheumatoid arthritis and lupus erythematosus.